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Literature DB >> 23812728

Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of diffuse large B cell lymphoma: a meta-analysis.

Yun-Yu Sun¹, Li An, Yu-Lan Xie, Jing-Yan Xu, Jing Wang.

Abstract

To date, case-control studies on the association between methylenetetrahydrofolate reductase (MTHFR) and diffuse large B cell lymphoma (DLBCL) have provided either controversial or inconclusive results. To clarify the effect of MTHFR on the risk of diffuse large B cell lymphoma, a meta-analysis of all case-control observational studies was performed. The fixed effects and random effects model showed that the C677T polymorphism was associated with a risk of DLBCL among East Asian populations, and A1298C polymorphism was not associated with a risk of DLBCL among Caucasian and East Asian populations. Our pooled data suggest evidence for a major role of MTHFR C677T polymorphism in the carcinogenesis of DLBCL among East Asian populations.

Entities: Disease Gene Mutation

Mesh：

Substances：

Year: 2013 PMID： 23812728 DOI： 10.1007/s13277-013-0938-1

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

22 in total

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Journal: Cancer Res Date: 1996-11-01 Impact factor: 12.701

4. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia.

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Journal: Blood Date: 2002-05-15 Impact factor: 22.113

5. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation.

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6. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage.

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7. Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma.

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Journal: Br J Haematol Date: 2003-03 Impact factor: 6.998

8. Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of follicular lymphoma: a meta-analysis.

Authors: Jing-Yan Xu; Yun-Yu Sun; Min Zhou; Jing Wang; Qi-Guo Zhang; Xi-Hui Xu; Hui Zeng; Jian Ouyang
Journal: Tumour Biol Date: 2013-01-29

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Authors: Kathrin Seidemann; Marion Book; Martin Zimmermann; Ulrike Meyer; Karl Welte; Martin Stanulla; Alfred Reiter
Journal: Ann Hematol Date: 2006-02-07 Impact factor: 3.673