C B O'Leary1, C Lehman, K Koltun, A Smith-Ryan, A C Hackney. 1. Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina, CB # 8700 Fetzer Hall, Chapel Hill, NC 27599, USA. coleary@live.unc.edu
Abstract
PURPOSE: To examine the androgen response to exercise in women under conditions of high (H) and low (L) estrogen (E2) levels. METHODS: Ten exercise trained eumenorrheic women (mean ± SD: 20.0 ± 2.2 years, 58.7 ± 8.3 kg, 22.3 ± 4.9 % body fat, VO2max = 50.7 ± 9.0 mL/kg/min) completed a 60 min treadmill run at ~70 % of VO2max during both the mid-follicular (L-E2, 69.7 ± 7.3 % VO2max) and mid-luteal (H-E2, 67.6 ± 7.9 % VO2max) phases of their menstrual cycle. Blood samples were taken pre-exercise (PRE), immediately post (POST), and 30 min into recovery (30R) from exercise and analyzed for total testosterone using ELISA assays. Results were analyzed using repeated measures ANOVA. RESULTS: Testosterone responses were (mean ± SD: L-E2, pre = 1.41 ± 0.21, post = 1.86 ± 0.21, 30R = 1.75 ± 0.32 nmol/L; H-E2, pre = 1.27 ± 0.23, post = 2.43 ± 0.56, 30R = 1.69 ± 0.34 nmol/L). Statistical analysis indicated no significant interaction existed between high and low estrogen conditions across the blood sampling times (p = 0.138). However, a main effect occurred for exercise (p < 0.004) with the post-testosterone concentration being greater than pre, although pre vs. 30R was not different (p > 0.05). All testosterone hormonal concentrations immediately post-exercise greatly exceeded the level of hemoconcentration observed during the L-E2 and H-E2 exercise sessions. CONCLUSIONS: Prolonged aerobic exercise induces short-term elevations in testosterone in trained eumenorrheic women, which appears unrelated to estrogen levels and menstrual cycle phase. These increases may occur due to either increased androgen production and/or decreased degradation rates of the hormone, and are not solely the result of plasma fluid shifts from the exercise.
PURPOSE: To examine the androgen response to exercise in women under conditions of high (H) and low (L) estrogen (E2) levels. METHODS: Ten exercise trained eumenorrheic women (mean ± SD: 20.0 ± 2.2 years, 58.7 ± 8.3 kg, 22.3 ± 4.9 % body fat, VO2max = 50.7 ± 9.0 mL/kg/min) completed a 60 min treadmill run at ~70 % of VO2max during both the mid-follicular (L-E2, 69.7 ± 7.3 % VO2max) and mid-luteal (H-E2, 67.6 ± 7.9 % VO2max) phases of their menstrual cycle. Blood samples were taken pre-exercise (PRE), immediately post (POST), and 30 min into recovery (30R) from exercise and analyzed for total testosterone using ELISA assays. Results were analyzed using repeated measures ANOVA. RESULTS:Testosterone responses were (mean ± SD: L-E2, pre = 1.41 ± 0.21, post = 1.86 ± 0.21, 30R = 1.75 ± 0.32 nmol/L; H-E2, pre = 1.27 ± 0.23, post = 2.43 ± 0.56, 30R = 1.69 ± 0.34 nmol/L). Statistical analysis indicated no significant interaction existed between high and low estrogen conditions across the blood sampling times (p = 0.138). However, a main effect occurred for exercise (p < 0.004) with the post-testosterone concentration being greater than pre, although pre vs. 30R was not different (p > 0.05). All testosterone hormonal concentrations immediately post-exercise greatly exceeded the level of hemoconcentration observed during the L-E2 and H-E2 exercise sessions. CONCLUSIONS: Prolonged aerobic exercise induces short-term elevations in testosterone in trained eumenorrheic women, which appears unrelated to estrogen levels and menstrual cycle phase. These increases may occur due to either increased androgen production and/or decreased degradation rates of the hormone, and are not solely the result of plasma fluid shifts from the exercise.
Authors: C Enea; N Boisseau; M Ottavy; J Mulliez; C Millet; I Ingrand; V Diaz; B Dugué Journal: Eur J Appl Physiol Date: 2009-03-12 Impact factor: 3.078
Authors: R R Kraemer; R J Heleniak; J L Tryniecki; G R Kraemer; N J Okazaki; V D Castracane Journal: Med Sci Sports Exerc Date: 1995-06 Impact factor: 5.411
Authors: Christopher T V Swain; Ann E Drummond; Leonessa Boing; Roger L Milne; Dallas R English; Kristy A Brown; Eline H van Roekel; Suzanne C Dixon-Suen; Michael J Lynch; Melissa M Moore; Tom R Gaunt; Richard M Martin; Sarah J Lewis; Brigid M Lynch Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-10-20 Impact factor: 4.254
Authors: Tomas K Tong; Julien S Baker; Fiona L Henriquez; Qingde Shi; Haifeng Zhang; Zhaowei Kong; Jinlei Nie Journal: Healthcare (Basel) Date: 2021-02-03