BACKGROUND: We examined the association between coronary artery calcifications, atherosclerotic burden, and plaque morphology in end-stage renal disease (ESRD) and non-ESRD patients undergoing 64-slice multidetector coronary computed tomographic angiography. METHODS: The prevalence, extent, and severity of coronary atherosclerosis, calcium burden, and plaque morphology were determined in ESRD patients (n=48), and calcium score-matched (n=39) and unmatched non-ESRD controls (n=29) undergoing computed tomographic angiography using dedicated plaque imaging software. RESULTS: ESRD was associated with a higher prevalence of calcified plaques (55.9% vs. 38.3 and 26.9% in the non-ESRD groups, P=0.005) and higher plaque calcium content (43.7 vs. 34.5% and 33.9%; P=0.003). Nonetheless, the calcium score correlated well with plaque burden (r=0.403 in ESRD vs. r=0.433 in non-ESRD, P<0.001 for both), and the diagnostic association between the calcium score and atherosclerotic lesions was good irrespective of ESRD (area under the curve 0.771 vs. 0.804; P=0.574). CONCLUSION: ESRD is associated with diffuse atherosclerosis and calcific plaque morphology. Nonetheless, the association between the calcium score and atherosclerotic burden is not affected by the presence of ESRD.
BACKGROUND: We examined the association between coronary artery calcifications, atherosclerotic burden, and plaque morphology in end-stage renal disease (ESRD) and non-ESRDpatients undergoing 64-slice multidetector coronary computed tomographic angiography. METHODS: The prevalence, extent, and severity of coronary atherosclerosis, calcium burden, and plaque morphology were determined in ESRDpatients (n=48), and calcium score-matched (n=39) and unmatched non-ESRD controls (n=29) undergoing computed tomographic angiography using dedicated plaque imaging software. RESULTS:ESRD was associated with a higher prevalence of calcified plaques (55.9% vs. 38.3 and 26.9% in the non-ESRD groups, P=0.005) and higher plaque calcium content (43.7 vs. 34.5% and 33.9%; P=0.003). Nonetheless, the calcium score correlated well with plaque burden (r=0.403 in ESRD vs. r=0.433 in non-ESRD, P<0.001 for both), and the diagnostic association between the calcium score and atherosclerotic lesions was good irrespective of ESRD (area under the curve 0.771 vs. 0.804; P=0.574). CONCLUSION:ESRD is associated with diffuse atherosclerosis and calcific plaque morphology. Nonetheless, the association between the calcium score and atherosclerotic burden is not affected by the presence of ESRD.
Authors: Thijs T Jansz; Meike H Y Go; Nolan S Hartkamp; J Lauran Stöger; Csilla Celeng; Tim Leiner; Pim A de Jong; Frank J L Visseren; Marianne C Verhaar; Brigit C van Jaarsveld Journal: Kidney Med Date: 2021-04-20
Authors: William E Moody; Erica L S Lin; Matthew Stoodley; David McNulty; Louise E Thomson; Daniel S Berman; Nicola C Edwards; Benjamin Holloway; Charles J Ferro; Jonathan N Townend; Richard P Steeds Journal: Am J Cardiol Date: 2016-02-17 Impact factor: 2.778