Heath A Eggleston1, Cameron F Gunville, Joshua I Miller, Marci K Sontag, Peter M Mourani. 1. From the *University of Colorado School of Medicine; †Section of Critical Care, Department of Pediatrics, University of Colorado Denver, Denver, Colorado; and ‡Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO.
Abstract
BACKGROUND: Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are among the leading causes of respiratory tract infections requiring admission to the pediatric intensive care unit (PICU). We evaluated the risk factors, clinical courses and outcomes of severe HMPV disease relative to severe RSV in children admitted to the PICU. METHODS: Retrospective chart review of children ≤18 years old admitted to a tertiary PICU between October 2008 through July 2010 with acute respiratory tract infection and positive direct antigen stain or polymerase chain reaction for RSV or HMPV. RESULTS: One hundred thirty-three patients met inclusion criteria: 107 (80.5%) with RSV and 26 (19.5%) with HMPV. HMPV-infected patients were older than RSV children (3.4 vs. 1.5 years, P = 0.002) and more likely to have congenital heart disease (34.6% vs. 10.3%, P = 0.002). Although HMPV children required longer duration of mechanical ventilation (11 vs. 7 days, P = 0.01), there were no other differences in hospital course. HMPV patients were more likely to be discharged receiving inhaled steroids (53.8% vs. 30.8%, P = 0.03), but there were no differences in other outcome assessments. CONCLUSIONS: Children admitted to the PICU with HMPV are significantly older and more likely to have congenital heart disease than those with RSV. The course of illness was similar between the 2 groups, but HMPV-infected children were more likely to be discharged with inhaled steroid therapy.
BACKGROUND:Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are among the leading causes of respiratory tract infections requiring admission to the pediatric intensive care unit (PICU). We evaluated the risk factors, clinical courses and outcomes of severe HMPV disease relative to severe RSV in children admitted to the PICU. METHODS: Retrospective chart review of children ≤18 years old admitted to a tertiary PICU between October 2008 through July 2010 with acute respiratory tract infection and positive direct antigen stain or polymerase chain reaction for RSV or HMPV. RESULTS: One hundred thirty-three patients met inclusion criteria: 107 (80.5%) with RSV and 26 (19.5%) with HMPV. HMPV-infectedpatients were older than RSVchildren (3.4 vs. 1.5 years, P = 0.002) and more likely to have congenital heart disease (34.6% vs. 10.3%, P = 0.002). Although HMPVchildren required longer duration of mechanical ventilation (11 vs. 7 days, P = 0.01), there were no other differences in hospital course. HMPVpatients were more likely to be discharged receiving inhaled steroids (53.8% vs. 30.8%, P = 0.03), but there were no differences in other outcome assessments. CONCLUSIONS:Children admitted to the PICU with HMPV are significantly older and more likely to have congenital heart disease than those with RSV. The course of illness was similar between the 2 groups, but HMPV-infectedchildren were more likely to be discharged with inhaled steroid therapy.
Authors: Leigh M Howard; Kathryn M Edwards; Yuwei Zhu; Carlos G Grijalva; Wesley H Self; Seema Jain; Krow Ampofo; Andrew T Pavia; Sandra R Arnold; Jonathan A McCullers; Evan J Anderson; Richard G Wunderink; Derek J Williams Journal: Clin Infect Dis Date: 2021-01-23 Impact factor: 9.079
Authors: Carly R Davis; Chris Stockmann; Andrew T Pavia; Carrie L Byington; Anne J Blaschke; Adam L Hersh; Emily A Thorell; Kent Korgenski; Judy Daly; Krow Ampofo Journal: J Pediatric Infect Dis Soc Date: 2015-05-20 Impact factor: 3.164
Authors: Nicolas Leister; Simone Commotio; Christoph Menzel; Sirin Yücetepe; Christoph Ulrichs; Stefanie Wendt; Christoph Dedden; Uwe Trieschmann; Tobias Hannes Journal: Cardiol Young Date: 2022-08-03 Impact factor: 1.023
Authors: Ioannis N Mammas; Anne Greenough; Maria Theodoridou; Anna Kramvis; Iliana Christaki; Chryssie Koutsaftiki; Maria Koutsaki; Dimitra M Portaliou; Georgia Kostagianni; Paraskevi Panagopoulou; George Sourvinos; Demetrios A Spandidos Journal: Exp Ther Med Date: 2015-11-24 Impact factor: 2.447