BACKGROUND: Non-small cell lung cancer (NSCLC) has a predilection to occur in emphysematous lungs. The relation between the regional severity of emphysema and the location of NSCLC as well as long-term survival has been poorly studied. METHODS: Computed tomography (CT) scans of 153 patients with biopsy-proven stage I NSCLC diagnosed between 2001 and 2006 were assigned an emphysema severity score in four regions of the lung. The location of the cancer was compared with the severity of emphysema in that region. Survival was also analyzed. RESULTS: Thirty-nine patients had no emphysema documented on CT scan and 114 did. The most common location of cancer was the right upper quadrant with 37% of cancers, followed by the left upper quadrant with 23% of cancers. Twenty-two percent of the cancers occurred in the right lower quadrant, and only 12% were in the left lower quadrant. There is a strong association for cancer being located in the area with the highest degree of emphysema (P < 0.001). Emphysema severity score was also associated with long-term survival (log-rank P = 0.03). CONCLUSIONS: The regional severity of emphysema assessed via a visual scale using CT appears to be associated with the location of lung cancer and is an independent predictor of long-term survival.
BACKGROUND:Non-small cell lung cancer (NSCLC) has a predilection to occur in emphysematous lungs. The relation between the regional severity of emphysema and the location of NSCLC as well as long-term survival has been poorly studied. METHODS: Computed tomography (CT) scans of 153 patients with biopsy-proven stage I NSCLC diagnosed between 2001 and 2006 were assigned an emphysema severity score in four regions of the lung. The location of the cancer was compared with the severity of emphysema in that region. Survival was also analyzed. RESULTS: Thirty-nine patients had no emphysema documented on CT scan and 114 did. The most common location of cancer was the right upper quadrant with 37% of cancers, followed by the left upper quadrant with 23% of cancers. Twenty-two percent of the cancers occurred in the right lower quadrant, and only 12% were in the left lower quadrant. There is a strong association for cancer being located in the area with the highest degree of emphysema (P < 0.001). Emphysema severity score was also associated with long-term survival (log-rank P = 0.03). CONCLUSIONS: The regional severity of emphysema assessed via a visual scale using CT appears to be associated with the location of lung cancer and is an independent predictor of long-term survival.
Authors: Jie Dai; Ming Liu; Stephen J Swensen; Shawn M Stoddard; Jason A Wampfler; Andrew H Limper; Gening Jiang; Ping Yang Journal: J Thorac Oncol Date: 2017-01-23 Impact factor: 15.609
Authors: Kyungsoo Bae; Kyung Nyeo Jeon; Seung Jun Lee; Ho Cheol Kim; Ji Young Ha; Sung Eun Park; Hye Jin Baek; Bo Hwa Choi; Soo Buem Cho; Jin Il Moon Journal: Medicine (Baltimore) Date: 2016-11 Impact factor: 1.889
Authors: Dámaso Parrón Collar; Mario Pazos Guerra; Paula Rodriguez; Carolina Gotera; Ignacio Mahíllo-Fernández; Germán Peces-Barba; Luis M Seijo Journal: Int J Chron Obstruct Pulmon Dis Date: 2017-03-30
Authors: Candice L Wilshire; Carson C Fuller; Christopher R Gilbert; John R Handy; Kimberly E Costas; Brian E Louie; Ralph W Aye; Alexander S Farivar; Eric Vallières; Jed A Gorden Journal: Can Respir J Date: 2020-03-26 Impact factor: 2.409