OBJECTIVE: To compare the effects of resistance and cardiovascular exercise on functional mobility in individuals with advanced cancer. DESIGN: Prospective, 2-group pretest-posttest pilot study with randomization to either resistance or cardiovascular exercise mode. SETTING:Comprehensive community cancer center and a hospital-based fitness facility. PARTICIPANTS: Volunteer sample of individuals (N=66; 30 men; 36 women; mean age, 62y) with advanced cancer recruited through the cancer center, palliative care service, rehabilitation department, and a local hospice. INTERVENTIONS: Ten weeks of individualized resistance or cardiovascular exercise, prescribed and monitored by oncology-trained exercise personnel. MAIN OUTCOME MEASURES: Functional mobility was assessed using the Short Physical Performance Battery (SPPB); self-reported pain and fatigue were assessed secondarily using visual analog scales. Data were analyzed using a split plot 2×2 analysis of variance (α=.05). RESULTS:Fifty-two patients (78.8%) completed the study: 23 (67.7%) of 34 patients in the resistance arm and 29 (90.6%) of 32 patients in the cardiovascular arm. No participant withdrew because of study adverse events. Ten-week outcomes (n=52) included a significant increase in SPPB total score (P<.001), increase in gait speed (P=.001), and reduction in fatigue (P=.05). Although cardiovascular exercise participants had a modestly greater improvement in SPPB total score than resistance training participants (F1,49=4.21, P=.045), the difference was not confirmed in a subsequent intention-to-treat analysis (N=66). CONCLUSIONS:Individuals with advanced cancer appear to benefit from exercise for improving functional mobility. Neither resistance nor cardiovascular exercise appeared to have a strong differential effect on outcome.
RCT Entities:
OBJECTIVE: To compare the effects of resistance and cardiovascular exercise on functional mobility in individuals with advanced cancer. DESIGN: Prospective, 2-group pretest-posttest pilot study with randomization to either resistance or cardiovascular exercise mode. SETTING: Comprehensive community cancer center and a hospital-based fitness facility. PARTICIPANTS: Volunteer sample of individuals (N=66; 30 men; 36 women; mean age, 62y) with advanced cancer recruited through the cancer center, palliative care service, rehabilitation department, and a local hospice. INTERVENTIONS: Ten weeks of individualized resistance or cardiovascular exercise, prescribed and monitored by oncology-trained exercise personnel. MAIN OUTCOME MEASURES: Functional mobility was assessed using the Short Physical Performance Battery (SPPB); self-reported pain and fatigue were assessed secondarily using visual analog scales. Data were analyzed using a split plot 2×2 analysis of variance (α=.05). RESULTS: Fifty-two patients (78.8%) completed the study: 23 (67.7%) of 34 patients in the resistance arm and 29 (90.6%) of 32 patients in the cardiovascular arm. No participant withdrew because of study adverse events. Ten-week outcomes (n=52) included a significant increase in SPPB total score (P<.001), increase in gait speed (P=.001), and reduction in fatigue (P=.05). Although cardiovascular exercise participants had a modestly greater improvement in SPPB total score than resistance training participants (F1,49=4.21, P=.045), the difference was not confirmed in a subsequent intention-to-treat analysis (N=66). CONCLUSIONS: Individuals with advanced cancer appear to benefit from exercise for improving functional mobility. Neither resistance nor cardiovascular exercise appeared to have a strong differential effect on outcome.
Authors: Maria C Swartz; Zakkoyya H Lewis; Elizabeth J Lyons; Kristofer Jennings; Addie Middleton; Rachel R Deer; Demi Arnold; Kaitlin Dresser; Kenneth J Ottenbacher; James S Goodwin Journal: Arch Phys Med Rehabil Date: 2017-04-17 Impact factor: 3.966
Authors: Marta K Mikkelsen; Cecilia M Lund; Anders Vinther; Anders Tolver; Julia S Johansen; Inna Chen; Anne-Mette Ragle; Bo Zerahn; Lotte Engell-Noerregaard; Finn O Larsen; Susann Theile; Dorte L Nielsen; Mary Jarden Journal: Oncologist Date: 2022-02-03 Impact factor: 5.837
Authors: Antonio Jose Grande; Valter Silva; Larissa Sawaris Neto; João Pedro Teixeira Basmage; Maria S Peccin; Matthew Maddocks Journal: Cochrane Database Syst Rev Date: 2021-03-18
Authors: Marta Kramer Mikkelsen; Cecilia Margareta Lund; Anders Vinther; Anders Tolver; Anne-Mette Ragle; Julia Sidenius Johansen; Inna Chen; Lotte Engell-Noerregaard; Finn Ole Larsen; Bo Zerahn; Dorte Lisbet Nielsen; Mary Jarden Journal: BMC Cancer Date: 2018-09-27 Impact factor: 4.430
Authors: Rebecca R Turner; Liz Steed; Helen Quirk; Rosa U Greasley; John M Saxton; Stephanie Jc Taylor; Derek J Rosario; Mohamed A Thaha; Liam Bourke Journal: Cochrane Database Syst Rev Date: 2018-09-19