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Literature DB >> 23810221

Pharmacotherapy for alcohol dependence: status of current treatments.

Abstract

The efficacy of medications for alcohol dependence remains modest, and there are no strong clinical predictors of treatment response. Approved medications include acamprosate (an N-methyl-d-aspartate receptor (NMDA) modulator), disulfiram (an acetaldehyde dehydrogenase inhibitor) and naltrexone (an opioid antagonist) while nalmefene (an opioid antagonist) is currently under review for approval in Europe. Clinical trials suggest that baclofen (a GABA-B agonist) and topiramate (an anticonvulsant) may be promising candidates, while several other drug candidates are currently evaluated at early clinical stages.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2013 PMID： 23810221 DOI： 10.1016/j.conb.2013.05.005

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

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Cited

28 in total

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