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Literature DB >> 23809605

Off-targets effects underlie the inhibitory effect of FAK inhibitors on platelet activation: studies using Fak-deficient mice.

M E Roh¹, M Cosgrove, K Gorski, I S Hitchcock.

Abstract

Entities: CellLine Chemical Disease Gene Species

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Year: 2013 PMID： 23809605 PMCID： PMC3932319 DOI： 10.1111/jth.12343

Source DB: PubMed Journal: J Thromb Haemost ISSN： 1538-7836 Impact factor: 5.824

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13 in total

1. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo.

Authors: Ralph Tiedt; Tibor Schomber; Hui Hao-Shen; Radek C Skoda
Journal: Blood Date: 2006-10-10 Impact factor: 22.113

2. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.

Authors: Ian S Hitchcock; Norma E Fox; Nicolas Prévost; Katherine Sear; Sanford J Shattil; Kenneth Kaushansky
Journal: Blood Date: 2007-10-09 Impact factor: 22.113

3. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands.

Authors: B Haimovich; L Lipfert; J S Brugge; S J Shattil
Journal: J Biol Chem Date: 1993-07-25 Impact factor: 5.157

4. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.

Authors: Walter Gregory Roberts; Ethan Ung; Pamela Whalen; Beth Cooper; Catherine Hulford; Christofer Autry; Daniel Richter; Earling Emerson; Jing Lin; John Kath; Kevin Coleman; Lili Yao; Luis Martinez-Alsina; Marianne Lorenzen; Martin Berliner; Michael Luzzio; Nandini Patel; Erika Schmitt; Susan LaGreca; Jitesh Jani; Matt Wessel; Eric Marr; Matt Griffor; Felix Vajdos
Journal: Cancer Res Date: 2008-03-15 Impact factor: 12.701

5. Protein kinase C regulates tyrosine phosphorylation of pp125FAK in platelets adherent to fibrinogen.

Authors: B Haimovich; N Kaneshiki; P Ji
Journal: Blood Date: 1996-01-01 Impact factor: 22.113

6. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.

Authors: S J Shattil; B Haimovich; M Cunningham; L Lipfert; J T Parsons; M H Ginsberg; J S Brugge
Journal: J Biol Chem Date: 1994-05-20 Impact factor: 5.157

7. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.

Authors: D J Sieg; D Ilić; K C Jones; C H Damsky; T Hunter; D D Schlaepfer
Journal: EMBO J Date: 1998-10-15 Impact factor: 11.598

Review 8. Focal adhesion kinase as a potential target in oncology.

Authors: Gordon W McLean; Egle Avizienyte; Margaret C Frame
Journal: Expert Opin Pharmacother Date: 2003-02 Impact factor: 3.889

9. The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.

Authors: L Cipolla; A Consonni; G Guidetti; I Canobbio; M Okigaki; M Falasca; E Ciraolo; E Hirsch; C Balduini; M Torti
Journal: J Thromb Haemost Date: 2013-02 Impact factor: 5.824

10. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

Authors: Sara M Weis; Ssang-Taek Lim; Kimberly M Lutu-Fuga; Leo A Barnes; Xiao Lei Chen; Joachim R Göthert; Tang-Long Shen; Jun-Lin Guan; David D Schlaepfer; David A Cheresh
Journal: J Cell Biol Date: 2008-04-07 Impact factor: 10.539

7 in total

Review 1. FAK in cancer: mechanistic findings and clinical applications.

Authors: Florian J Sulzmaier; Christine Jean; David D Schlaepfer
Journal: Nat Rev Cancer Date: 2014-08-07 Impact factor: 60.716

2. Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation.

Authors: Naadiya Carrim; Tony G Walsh; Alessandra Consonni; Mauro Torti; Michael C Berndt; Pat Metharom
Journal: PLoS One Date: 2014-11-21 Impact factor: 3.240

3. Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.

Authors: Praveena S Thiagarajan; Maksim Sinyuk; Soumya M Turaga; Erin E Mulkearns-Hubert; James S Hale; Vinay Rao; Abeba Demelash; Caner Saygin; Arnab China; Tyler J Alban; Masahiro Hitomi; Luke A Torre-Healy; Alvaro G Alvarado; Awad Jarrar; Andrew Wiechert; Valery Adorno-Cruz; Paul L Fox; Benjamin C Calhoun; Jun-Lin Guan; Huiping Liu; Ofer Reizes; Justin D Lathia
Journal: Nat Commun Date: 2018-02-08 Impact factor: 14.919