Andrea Weghofer1, Ann Kim, David H Barad, Norbert Gleicher. 1. Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria; Center for Human Reproduction and Foundation for Reproductive Medicine, New York, New York. Electronic address: andrea.weghofer@meduniwien.ac.at.
Abstract
OBJECTIVE: To investigate whether age at menarche is associated with functional ovarian reserve (FOR) later in life. DESIGN: Retrospective cohort study. SETTING: Fertility center. PATIENT(S): Five hundred and two infertile women. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Levels of menarcheal age, antimüllerian hormone (AMH), follicle-stimulating hormone (FSH), and functional ovarian reserve. RESULT(S): The mean age of the patients was 38.9 ± 4.9 years, and their mean level of AMH was 1.4 ± 2.0 ng/mL and of FSH was 10.7 ± 6.1 mIU/mL. Their current age-specific diminished functional ovarian reserve (DFOR) was statistically significantly associated with early menarche, defined as age <13 years. Logistic regression analysis, adjusting for race, affirmed the higher likelihood of early age at menarche in infertile patients with DFOR. When women with DFOR were grouped into quartiles, early menarche (<25th percentile) was associated with statistically significantly higher DFOR risk than late menarche (>75th percentile). CONCLUSION(S): This study demonstrates a statistically significant impact of age at menarche on DFOR risk later in life among infertile women. The occurrence of menarche may relate to follicular pool size and/or speed of follicle recruitment, which in turn is predictive of occurrence of DFOR later in life.
OBJECTIVE: To investigate whether age at menarche is associated with functional ovarian reserve (FOR) later in life. DESIGN: Retrospective cohort study. SETTING: Fertility center. PATIENT(S): Five hundred and two infertile women. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Levels of menarcheal age, antimüllerian hormone (AMH), follicle-stimulating hormone (FSH), and functional ovarian reserve. RESULT(S): The mean age of the patients was 38.9 ± 4.9 years, and their mean level of AMH was 1.4 ± 2.0 ng/mL and of FSH was 10.7 ± 6.1 mIU/mL. Their current age-specific diminished functional ovarian reserve (DFOR) was statistically significantly associated with early menarche, defined as age <13 years. Logistic regression analysis, adjusting for race, affirmed the higher likelihood of early age at menarche in infertile patients with DFOR. When women with DFOR were grouped into quartiles, early menarche (<25th percentile) was associated with statistically significantly higher DFOR risk than late menarche (>75th percentile). CONCLUSION(S): This study demonstrates a statistically significant impact of age at menarche on DFOR risk later in life among infertile women. The occurrence of menarche may relate to follicular pool size and/or speed of follicle recruitment, which in turn is predictive of occurrence of DFOR later in life.
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