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Literature DB >> 23809227

Cantharidin-based small molecules as potential therapeutic agents.

Carlos E Puerto Galvis¹, Leonor Y Vargas Méndez, Vladimir V Kouznetsov.

Abstract

Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006-2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.

Entities: Chemical Disease

Keywords: Diels-Alder cycloaddition reactions; anticancer activity; blister beetles; cantharidin analogs; drug design and development; protein phosphatases inhibitory activity

Mesh：

Substances：

Year: 2013 PMID： 23809227 DOI： 10.1111/cbdd.12180

Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817

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Cited

21 in total

1. Synthesis and anticancer activity evaluation of 3,4-mono- and bicyclosubstituted N-(het)aryl trifluoromethyl succinimides.

Authors: Elena L Luzina; Anatoliy V Popov
Journal: J Fluor Chem Date: 2014-12 Impact factor: 2.050

2. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC.

Authors: Y Xi; D M Garshott; A L Brownell; G H Yoo; H-S Lin; T L Freeburg; N G Yoo; R J Kaufman; M U Callaghan; A M Fribley
Journal: J Dent Res Date: 2014-11-25 Impact factor: 6.116

3. Protective Effect of Norcantharidin on Collagen-Induced Arthritis Rats.

Authors: Hong-Bo Shen; Ze-Jun Huo; Yun-Jing Bai; Xiao-Juan He; Chang-Hong Li; Yu-Kun Zhao; Qing-Qing Guo
Journal: Chin J Integr Med Date: 2017-12-21 Impact factor: 1.978

4. Chemical-Switching Strategy for Synthesis and Controlled Release of Norcantharimides from a Biomass-Derived Chemical.

Authors: Hochan Chang; George W Huber; James A Dumesic
Journal: ChemSusChem Date: 2020-08-25 Impact factor: 8.928

Review 5. Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives.

Authors: Yulin Ren; A Douglas Kinghorn
Journal: Bioorg Med Chem Date: 2021-01-09 Impact factor: 3.641

6. Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-Regulated Mitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways.

Authors: Chin-Chuan Su; Kuan-I Lee; Mu-Kuan Chen; Chun-Ying Kuo; Chih-Hsin Tang; Shing Hwa Liu
Journal: PLoS One Date: 2016-12-08 Impact factor: 3.240

Cantharidin-based small molecules as potential therapeutic agents.

1. Synthesis and anticancer activity evaluation of 3,4-mono- and bicyclosubstituted N-(het)aryl trifluoromethyl succinimides.

2. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC.

3. Protective Effect of Norcantharidin on Collagen-Induced Arthritis Rats.

4. Chemical-Switching Strategy for Synthesis and Controlled Release of Norcantharimides from a Biomass-Derived Chemical.

Review 5. Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives.

6. Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-Regulated Mitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways.

Review 7. Insects: an underrepresented resource for the discovery of biologically active natural products.

8. Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets.

9. Induction of Suicidal Erythrocyte Death by Cantharidin.

Review 10. Recent advances in developing insect natural products as potential modern day medicines.