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Literature DB >> 23809156

Costimulatory genes: hotspots of conflict between host defense and autoimmunity.

Abstract

To understand the adaptations of costimulatory molecules through mammalian evolution, Forni et al. (Forni et al., 2013) studied evolutionary selection in key costimulatory genes. Their results, presented in this issue of Immunity, suggest that the risk of autoimmmunity is balanced against efficacy of the anti-pathogen immune response.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2013 PMID： 23809156 PMCID： PMC3773510 DOI： 10.1016/j.immuni.2013.06.008

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

10 in total

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Authors: Rosemarie H DeKruyff; Xia Bu; Angela Ballesteros; César Santiago; Yee-Ling E Chim; Hyun-Hee Lee; Piia Karisola; Muriel Pichavant; Gerardo G Kaplan; Dale T Umetsu; Gordon J Freeman; José M Casasnovas
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7. A 175 million year history of T cell regulatory molecules reveals widespread selection, with adaptive evolution of disease alleles.

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8. The date of interbreeding between Neandertals and modern humans.

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Journal: PLoS Genet Date: 2012-10-04 Impact factor: 5.917

9. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors: Luke Jostins; Stephan Ripke; Rinse K Weersma; Richard H Duerr; Dermot P McGovern; Ken Y Hui; James C Lee; L Philip Schumm; Yashoda Sharma; Carl A Anderson; Jonah Essers; Mitja Mitrovic; Kaida Ning; Isabelle Cleynen; Emilie Theatre; Sarah L Spain; Soumya Raychaudhuri; Philippe Goyette; Zhi Wei; Clara Abraham; Jean-Paul Achkar; Tariq Ahmad; Leila Amininejad; Ashwin N Ananthakrishnan; Vibeke Andersen; Jane M Andrews; Leonard Baidoo; Tobias Balschun; Peter A Bampton; Alain Bitton; Gabrielle Boucher; Stephan Brand; Carsten Büning; Ariella Cohain; Sven Cichon; Mauro D'Amato; Dirk De Jong; Kathy L Devaney; Marla Dubinsky; Cathryn Edwards; David Ellinghaus; Lynnette R Ferguson; Denis Franchimont; Karin Fransen; Richard Gearry; Michel Georges; Christian Gieger; Jürgen Glas; Talin Haritunians; Ailsa Hart; Chris Hawkey; Matija Hedl; Xinli Hu; Tom H Karlsen; Limas Kupcinskas; Subra Kugathasan; Anna Latiano; Debby Laukens; Ian C Lawrance; Charlie W Lees; Edouard Louis; Gillian Mahy; John Mansfield; Angharad R Morgan; Craig Mowat; William Newman; Orazio Palmieri; Cyriel Y Ponsioen; Uros Potocnik; Natalie J Prescott; Miguel Regueiro; Jerome I Rotter; Richard K Russell; Jeremy D Sanderson; Miquel Sans; Jack Satsangi; Stefan Schreiber; Lisa A Simms; Jurgita Sventoraityte; Stephan R Targan; Kent D Taylor; Mark Tremelling; Hein W Verspaget; Martine De Vos; Cisca Wijmenga; David C Wilson; Juliane Winkelmann; Ramnik J Xavier; Sebastian Zeissig; Bin Zhang; Clarence K Zhang; Hongyu Zhao; Mark S Silverberg; Vito Annese; Hakon Hakonarson; Steven R Brant; Graham Radford-Smith; Christopher G Mathew; John D Rioux; Eric E Schadt; Mark J Daly; Andre Franke; Miles Parkes; Severine Vermeire; Jeffrey C Barrett; Judy H Cho
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10. An integrated map of genetic variation from 1,092 human genomes.

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Journal: Nature Date: 2012-11-01 Impact factor: 49.962