Robby Kumar1. 1. Department of Biochemistry, SSR Medical College, Mauritius.
Abstract
OBJECTIVE: This study aims to establish a link between the lipid composition of red blood cell membrane and serum to aid in the early diagnosis and treatment of patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Diabetic subjects with and without dyslipidemia were selected along with healthy control subjects. Biochemical changes in serum and erythrocyte membrane were compared in study groups. RESULTS: The lipid composition of membrane was significantly altered with increased cholesterol:Phospholipid ratio and decreased Na + K + -ATPase of membrane upon comparison with control subjects. CONCLUSION: Increased hyperglycemia with altered serum lipid composition in diabetes mellitus causes glycation of membrane enzymes this along with oxidative stress leads to decrease in activity of Na + K + -ATPase and other changes in erythrocyte membrane. Significant findings of the study: As the lipid level increases there is increased lipid peroxidation and the membrane composition gets altered.
OBJECTIVE: This study aims to establish a link between the lipid composition of red blood cell membrane and serum to aid in the early diagnosis and treatment of patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Diabetic subjects with and without dyslipidemia were selected along with healthy control subjects. Biochemical changes in serum and erythrocyte membrane were compared in study groups. RESULTS: The lipid composition of membrane was significantly altered with increased cholesterol:Phospholipid ratio and decreased Na + K + -ATPase of membrane upon comparison with control subjects. CONCLUSION: Increased hyperglycemia with altered serum lipid composition in diabetes mellitus causes glycation of membrane enzymes this along with oxidative stress leads to decrease in activity of Na + K + -ATPase and other changes in erythrocyte membrane. Significant findings of the study: As the lipid level increases there is increased lipid peroxidation and the membrane composition gets altered.
Authors: Viktor V Revin; Svetlana M Filatova; Ilya V Syusin; Marina Yu Yazykova; Elvira S Revina; Natalia V Gromova; Arkadiy A Devyatkin Journal: Int J Hematol Date: 2015-02-24 Impact factor: 2.490