| Literature DB >> 23806555 |
Yosuke Demizu1, Saori Nagoya, Manami Shirakawa, Megumi Kawamura, Nanako Yamagata, Yukiko Sato, Mitsunobu Doi, Masaaki Kurihara.
Abstract
We synthesized stapled helical leucine-based peptides (DPI-01-07) containing 2-aminoisobutyric acid and a covalent cross-linked unit as inhibitors of vitamin D receptor (VDR)-coactivator interactions. The effects of these peptides on the human VDR were examined in an inhibition assay based on the receptor cofactor assay system, and one of them, DPI-07, exhibited potent inhibitory activity (IC₅₀: 3.2 μM).Entities:
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Year: 2013 PMID： 23806555 DOI： 10.1016/j.bmcl.2013.06.002
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823