Literature DB >> 2380653

Glucagon-like peptide-1 (7-36)-NH2: a physiological inhibitor of gastric acid secretion in man.

D J O'Halloran1, G C Nikou, B Kreymann, M A Ghatei, S R Bloom.   

Abstract

Glucagon-like peptide (GLP)-1 (7-36)-NH2 is a peptide found in the mucosal endocrine cells of the intestine, and plasma levels of GLP-1 (7-36)-NH2 immunoreactivity show a rise after the ingestion of a fat or mixed-component meal. We investigated the effects of physiological infusion of GLP-1 (7-36)-NH2 on a submaximal gastric acid secretion in healthy volunteers at a rate known to mimic the observed postprandial rise in plasma concentrations. Corrected gastric acid output decreased to less than 50% and volume output to 33% of stimulated values. After the infusion, the secretion of gastric acid recovered immediately to preinhibition values. These results suggest a novel role for GLP-1 (7-36)-NH2 as a physiological inhibitor of gastric acid secretion in man.

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Year:  1990        PMID： 2380653     DOI： 10.1677/joe.0.1260169

Source DB:  PubMed          Journal:  J Endocrinol        ISSN： 0022-0795            Impact factor:   4.286


  14 in total

1.  The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation.

Authors:  A Wettergren; M Wøjdemann; S Meisner; F Stadil; J J Holst
Journal:  Gut       Date:  1997-05       Impact factor: 23.059

2.  Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.

Authors:  J Schirra; K Sturm; P Leicht; R Arnold; B Göke; M Katschinski
Journal:  J Clin Invest       Date:  1998-04-01       Impact factor: 14.808

3.  The effect of some gastrointestinal peptides on pentagastrin-stimulated acid secretion and oxyntic mucosal histamine in rats.

Authors:  A Ben-Hamida; W K Man; J Spencer
Journal:  Inflamm Res       Date:  1996-03       Impact factor: 4.575

4.  GLP-1 receptor is expressed in human stomach mucosa: analysis of its cellular association and distribution within gastric glands.

Authors:  Efrat Broide; Olga Bloch; Gilad Ben-Yehudah; Dror Cantrell; Haim Shirin; Micha J Rapoport
Journal:  J Histochem Cytochem       Date:  2013-06-26       Impact factor: 2.479

Review 5.  All bariatric surgeries are not created equal: insights from mechanistic comparisons.

Authors:  Margaret A Stefater; Hilary E Wilson-Pérez; Adam P Chambers; Darleen A Sandoval; Randy J Seeley
Journal:  Endocr Rev       Date:  2012-05-01       Impact factor: 19.871

6.  Ileal carbohydrates inhibit cholinergically stimulated exocrine pancreatic secretion in humans.

Authors:  G Gröger; A Unger; J J Holst; H Goebell; P Layer
Journal:  Int J Pancreatol       Date:  1997-08

7.  Duodenal infusion of fatty acids differentially affects plasma glucagon-like peptide-1 and ghrelin concentrations in sheep.

Authors:  Rika Fukumori; Yoji Masuda; Ayaka Takeuchi; Rina Yanai; Khurchabiling Atchalalt; Borjigin Sarentonglaga; Kazuko Ogata; Mio Yamaguchi; Asuka Hara; Akane Sato; Toshihisa Sugino; Yoshikazu Nagao
Journal:  J Anim Sci       Date:  2018-05-04       Impact factor: 3.159

8.  Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man.

Authors:  A Wettergren; B Schjoldager; P E Mortensen; J Myhre; J Christiansen; J J Holst
Journal:  Dig Dis Sci       Date:  1993-04       Impact factor: 3.199

Review 9.  Glucagon-like peptide-1, a new hormone of the entero-insular axis.

Authors:  C Orskov
Journal:  Diabetologia       Date:  1992-08       Impact factor: 10.122

10.  Ileal release of glucagon-like peptide-1 (GLP-1). Association with inhibition of gastric acid secretion in humans.

Authors:  P Layer; J J Holst; D Grandt; H Goebell
Journal:  Dig Dis Sci       Date:  1995-05       Impact factor: 3.199
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