| Literature DB >> 23806233 |
Norikazu Tsunekawa-Imai1, Hiroshi Miwa, Masato Shikami, Kazuto Suganuma, Mineaki Goto, Shohei Mizuno, Miyuki Takahashi, Motonori Mizutani, Tomohiro Horio, Hiroko Komatsubara, Mayuko Gotou, Hidesuke Yamamoto, Motohiro Wakabayashi, Masaya Watarai, Ichiro Hanamura, Akira Imamura, Hidetsugu Mihara, Masakazu Nitta.
Abstract
We examined the effects of diet nutrients on xenotransplanted leukemia cells, THP-1 or NB4. THP-1 tumors showed more growth when fed with high fat diet, while NB4 tumors grew more with high carbohydrate diet. Then, administration of 2-deoxyglucose (a glycolysis inhibitor) showed a significant antitumor effect on both tumors: NB4 tumor showed large necrotic areas, while THP-1 tumor did not, but had augmented expression of enzymes for fatty acid oxidation. 2-Deoxyglucose inhibited the growth of NB4 by cell death because main energy producing pathway (glycolysis) was abolished, while 2-deoxyglucose slowed the growth of THP-1 by shifting energy metabolism to fatty acid β-oxidation.Entities:
Keywords: 2-Deoxyglucose (2-DG); AML; Carbohydrate-dominant diet; Etomoxir; High fat diet; Xenotransplantation
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Year: 2013 PMID： 23806233 DOI： 10.1016/j.leukres.2013.05.017
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156