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Literature DB >> 23806201

Impact of aging on antigen presentation cell function of dendritic cells.

Abstract

Older people exhibit increased mortality to infections and cancer as compared to younger people, indicating that aging impairs immunity. Dendritic cells (DCs) are key for bridging the innate and adaptive arms of the immune system by priming antigen specific T cells. Discerning how aging impacts DC function to initiate adaptive immune responses is of great biomedical importance as this could lead to the development of novel therapeutics to enhance immunity with aging. This review details reports indicating that aging impairs the antigen presenting function of DCs but highlights other studies indicating preserved DC function with aging. How aging impacts antigen presentation by DCs is complex and without a clear unifying biological underpinning.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2013 PMID： 23806201 PMCID： PMC3775944 DOI： 10.1016/j.coi.2013.05.016

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

39 in total

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Journal: Cell Date: 2001-08-10 Impact factor: 41.582

Review 2. Immunity to influenza: the challenges of protecting an aging population.

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Journal: Immunol Res Date: 2004 Impact factor: 2.829

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Authors: Taro Kawai; Shizuo Akira
Journal: Ann N Y Acad Sci Date: 2008-11 Impact factor: 5.691

4. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.

Authors: Jincun Zhao; Jingxian Zhao; Kevin Legge; Stanley Perlman
Journal: J Clin Invest Date: 2011-11-21 Impact factor: 14.808

5. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging.

Authors: Bethany M Tesar; Wendy E Walker; Julia Unternaehrer; Nikhil S Joshi; Anmol Chandele; Laura Haynes; Susan Kaech; Daniel R Goldstein
Journal: Aging Cell Date: 2006-12 Impact factor: 9.304

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Journal: Science Date: 2010-02-05 Impact factor: 47.728

7. Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection.

Authors: Heather W Stout-Delgado; Wei Du; Anushree C Shirali; Carmen J Booth; Daniel R Goldstein
Journal: Cell Host Microbe Date: 2009-11-19 Impact factor: 21.023

8. Alterations in dendritic cell function in aged mice: potential implications for immunotherapy design.

Authors: Carine Paula; Adriana Motta; Carla Schmitz; Claudia P Nunes; Ana Paula Souza; Cristina Bonorino
Journal: Biogerontology Date: 2008-06-13 Impact factor: 4.277

9. Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection.

Authors: Jason P Gigley; Imtiaz A Khan
Journal: PLoS One Date: 2011-06-10 Impact factor: 3.240

10. Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium.

Authors: Gang Li; Megan J Smithey; Brian D Rudd; Janko Nikolich-Žugich
Journal: Aging Cell Date: 2012-08-30 Impact factor: 9.304

40 in total

Review 1. The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span.

Authors: Primož Rožman
Journal: Geroscience Date: 2018-06-14 Impact factor: 7.713

Review 2. Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart.

Authors: Phyllis-Jean Linton; Marilyn L Thoman
Journal: Immunol Lett Date: 2014-09-22 Impact factor: 3.685

3. Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity.

Authors: Alex G Peniche; Jennifer K Spinler; Prapaporn Boonma; Tor C Savidge; Sara M Dann
Journal: Anaerobe Date: 2018-08-09 Impact factor: 3.331

Review 4. Age-dependent dysregulation of innate immunity.

Authors: Albert C Shaw; Daniel R Goldstein; Ruth R Montgomery
Journal: Nat Rev Immunol Date: 2013-10-25 Impact factor: 53.106

Review 5. Influenza Pathogenesis: The Effect of Host Factors on Severity of Disease.

Authors: Anshu P Gounder; Adrianus C M Boon
Journal: J Immunol Date: 2019-01-15 Impact factor: 5.422

Review 6. Successful and Maladaptive T Cell Aging.

Authors: Jörg J Goronzy; Cornelia M Weyand
Journal: Immunity Date: 2017-03-21 Impact factor: 31.745

7. IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo.

Authors: Vinayak Brahmakshatriya; Yi Kuang; Priyadharshini Devarajan; Jingya Xia; Wenliang Zhang; Allen Minh Vong; Susan L Swain
Journal: J Immunol Date: 2017-03-01 Impact factor: 5.422

8. Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction.

Authors: Claire A Chougnet; Robert I Thacker; Hesham M Shehata; Cassandra M Hennies; Maria A Lehn; Celine S Lages; Edith M Janssen
Journal: J Immunol Date: 2015-08-05 Impact factor: 5.422

9. Age and Periodontal Health - Immunological View.

Authors: J L Ebersole; D A Dawson; P Emecen Huja; S Pandruvada; A Basu; L Nguyen; Y Zhang; O A Gonzalez
Journal: Curr Oral Health Rep Date: 2018-11-07

Review 10. Geriatrics and COVID-19.

Authors: Mona Mirbeyk; Amene Saghazadeh; Nima Rezaei
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622