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Literature DB >> 23804635

Palmitoylation on conserved and nonconserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity.

Jocelyn C Hach¹, Temet McMichael, Nicholas M Chesarino, Jacob S Yount.

Abstract

The interferon-induced transmembrane proteins (IFITMs) restrict infection by numerous viruses, yet the importance and regulation of individual isoforms remains unclear. Here, we report that murine IFITM1 (mIFITM1) is palmitoylated on one nonconserved cysteine and three conserved cysteines that are required for anti-influenza A virus activity. Additionally, palmitoylation of mIFITM1 regulates protein stability by preventing proteasomal degradation, and modification of the nonconserved cysteine at the mIFITM1 C terminus supports an intramembrane topology with mechanistic implications.

Entities: Chemical Disease Gene Species

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Year: 2013 PMID： 23804635 PMCID： PMC3754091 DOI： 10.1128/JVI.00621-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

28 in total

1. Identification of PSD-95 palmitoylating enzymes.

Authors: Masaki Fukata; Yuko Fukata; Hillel Adesnik; Roger A Nicoll; David S Bredt
Journal: Neuron Date: 2004-12-16 Impact factor: 17.173

Review 2. Sheets, ribbons and tubules - how organelles get their shape.

Authors: Gia K Voeltz; William A Prinz
Journal: Nat Rev Mol Cell Biol Date: 2007-02-07 Impact factor: 94.444

Review 3. DHHC palmitoyl transferases: substrate interactions and (patho)physiology.

Authors: Jennifer Greaves; Luke H Chamberlain
Journal: Trends Biochem Sci Date: 2011-03-08 Impact factor: 13.807

4. Characterization of the fusogenic properties of Sendai virus: kinetics of fusion with erythrocyte membranes.

Authors: D Hoekstra; K Klappe; T de Boer; J Wilschut
Journal: Biochemistry Date: 1985-08-27 Impact factor: 3.162

5. Cysteine 29 is the major palmitoylation site on stomatin.

Authors: L Snyers; E Umlauf; R Prohaska
Journal: FEBS Lett Date: 1999-04-23 Impact factor: 4.124

6. Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.

Authors: Jacob S Yount; Bruno Moltedo; Yu-Ying Yang; Guillaume Charron; Thomas M Moran; Carolina B López; Howard C Hang
Journal: Nat Chem Biol Date: 2010-07-04 Impact factor: 15.040

7. IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.

Authors: Eric M Feeley; Jennifer S Sims; Sinu P John; Christopher R Chin; Thomas Pertel; Li-Mei Chen; Gaurav D Gaiha; Bethany J Ryan; Ruben O Donis; Stephen J Elledge; Abraham L Brass
Journal: PLoS Pathog Date: 2011-10-27 Impact factor: 6.823

Review 8. The broad-spectrum antiviral functions of IFIT and IFITM proteins.

Authors: Michael S Diamond; Michael Farzan
Journal: Nat Rev Immunol Date: 2012-12-14 Impact factor: 53.106

9. Ifitm3 limits the severity of acute influenza in mice.

Authors: Charles C Bailey; I-Chueh Huang; Christina Kam; Michael Farzan
Journal: PLoS Pathog Date: 2012-09-06 Impact factor: 6.823

10. IFITM proteins restrict viral membrane hemifusion.

Authors: Kun Li; Ruben M Markosyan; Yi-Min Zheng; Ottavia Golfetto; Brittani Bungart; Minghua Li; Shilei Ding; Yuxian He; Chen Liang; James C Lee; Enrico Gratton; Fredric S Cohen; Shan-Lu Liu
Journal: PLoS Pathog Date: 2013-01-24 Impact factor: 6.823

44 in total

1. Duck Interferon-Inducible Transmembrane Protein 3 Mediates Restriction of Influenza Viruses.

Authors: Graham A D Blyth; Wing Fuk Chan; Robert G Webster; Katharine E Magor
Journal: J Virol Date: 2015-10-14 Impact factor: 5.103

2. Distinct palmitoylation events at the amino-terminal conserved cysteines of Env7 direct its stability, localization, and vacuolar fusion regulation in S. cerevisiae.

Authors: Surya P Manandhar; Erika N Calle; Editte Gharakhanian
Journal: J Biol Chem Date: 2014-03-07 Impact factor: 5.157

10. The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.

Authors: Temet M McMichael; Lizhi Zhang; Mahesh Chemudupati; Jocelyn C Hach; Adam D Kenney; Howard C Hang; Jacob S Yount
Journal: J Biol Chem Date: 2017-10-27 Impact factor: 5.157

Palmitoylation on conserved and nonconserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity.

1. Identification of PSD-95 palmitoylating enzymes.

Review 2. Sheets, ribbons and tubules - how organelles get their shape.

Review 3. DHHC palmitoyl transferases: substrate interactions and (patho)physiology.

4. Characterization of the fusogenic properties of Sendai virus: kinetics of fusion with erythrocyte membranes.

5. Cysteine 29 is the major palmitoylation site on stomatin.

6. Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3.

7. IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.

Review 8. The broad-spectrum antiviral functions of IFIT and IFITM proteins.

9. Ifitm3 limits the severity of acute influenza in mice.

10. IFITM proteins restrict viral membrane hemifusion.

1. Duck Interferon-Inducible Transmembrane Protein 3 Mediates Restriction of Influenza Viruses.

2. Distinct palmitoylation events at the amino-terminal conserved cysteines of Env7 direct its stability, localization, and vacuolar fusion regulation in S. cerevisiae.

Review 3. Regulation of the trafficking and antiviral activity of IFITM3 by post-translational modifications.

4. IFITM3 requires an amphipathic helix for antiviral activity.

5. Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.

6. Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.

7. IFITM3 Restricts Human Metapneumovirus Infection.

8. Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes.

9. Interferon-induced transmembrane protein 3 is a type II transmembrane protein.

10. The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.