Literature DB >> 23804305

Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants.

Tianfeng Xu1, Lianwen Zhang, Shilin Xu, Chao-Yie Yang, Jinfeng Luo, Fang Ding, Xiaoyun Lu, Yingxue Liu, Zhengchao Tu, Shiliang Li, Duanqing Pei, Qian Cai, Honglin Li, Xiaomei Ren, Shaomeng Wang, Ke Ding.   

Abstract

Entities:  

Keywords:  T790M mutants; drug design; inhibitors; selectivity

Mesh：

Substances：

Year:  2013        PMID： 23804305     DOI： 10.1002/anie.201302313

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  6 in total

1.  Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.

Authors:  Ryan P Wurz; Liping H Pettus; Kate Ashton; James Brown; Jian Jeffrey Chen; Brad Herberich; Fang-Tsao Hong; Essa Hu-Harrington; Tom Nguyen; David J St Jean; Seifu Tadesse; David Bauer; Michele Kubryk; Jinghui Zhan; Keegan Cooke; Petia Mitchell; Kristin L Andrews; Faye Hsieh; Dean Hickman; Nataraj Kalyanaraman; Tian Wu; Darren L Reid; Edward K Lobenhofer; Dina A Andrews; Nancy Everds; Roberto Guzman; Andrew T Parsons; Simon J Hedley; Jason Tedrow; Oliver R Thiel; Matthew Potter; Robert Radinsky; Pedro J Beltran; Andrew S Tasker
Journal:  ACS Med Chem Lett       Date:  2015-07-27       Impact factor: 4.345

2.  Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy.

Authors:  Xiaoyun Lu; Tao Zhang; Su-Jie Zhu; Qiuju Xun; Lingjiang Tong; Xianglong Hu; Yan Li; Shingpan Chan; Yi Su; Yiming Sun; Yi Chen; Jian Ding; Cai-Hong Yun; Hua Xie; Ke Ding
Journal:  ACS Med Chem Lett       Date:  2018-10-08       Impact factor: 4.345

3.  Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a N,9-Diphenyl-9H-purin-2-amine Scaffold.

Authors:  Yang Ge; Yue Jin; Changyuan Wang; Jianbin Zhang; Zeyao Tang; Jinyong Peng; Kexin Liu; Yanxia Li; Youwen Zhou; Xiaodong Ma
Journal:  ACS Med Chem Lett       Date:  2016-09-21       Impact factor: 4.345

4.  Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors.

Authors:  Amany Belal; Nagwa M Abdel Gawad; Ahmed B M Mehany; Mohammed A S Abourehab; Hazem Elkady; Ahmed A Al-Karmalawy; Ahmed S Ismael
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

5.  YL143, a novel mutant selective irreversible EGFR inhibitor, overcomes EGFRL858R, T790M -mutant resistance in vitro and in vivo.

Authors:  Zhang Zhang; Jian Zou; Lei Yu; Jinfeng Luo; Yan Li; Zhengchao Tu; Xiaomei Ren; Hongcheng Wei; Liyan Song; Xiaoyun Lu; Ke Ding
Journal:  Cancer Med       Date:  2018-03-13       Impact factor: 4.452

6.  The increasing impact of Chinese innovative drug research on the global stage with a focus on drug discovery.

Authors:  Wei Luo; Cherukupalli Srinivasulu; Xia Hao; Xinyong Liu; Peng Zhan
Journal:  Expert Opin Drug Discov       Date:  2020-06-17       Impact factor: 6.098
  6 in total

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