| Literature DB >> 23804073 |
Hui Yang1, Xianghui Wang, Yan Zhang, Huanrong Liu, Jiongbo Liao, Kun Shao, Yiwei Chu, Guangwei Liu.
Abstract
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which has a central role in the regulation of cell growth and metabolism. In the study of the mTOR signaling pathway, tuberous sclerosis complex (TSC) 1/2 complex is identified as a critical regulator of mTOR activity. TSC1/2 plays important roles for immune cell homeostasis and differentiation by negative control of mTOR signaling pathway. TSC1/2-mTOR pathway is proving to be a central point in regulating immune function of diverse immune cells. In this review, we discuss the function of TSC1/2-mTOR to direct the innate and adaptive immune cell development and function. Furthermore, we focus on the role of TSC1/2-mTOR signaling pathway in immune cell mediated diseases, especially autoimmunity.Entities:
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Year: 2014 PMID： 23804073 DOI： 10.1002/jcp.24426
Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384