Literature DB >> 2380391

The 83-kilodalton antigen of Borrelia burgdorferi which stimulates immunoglobulin M (IgM) and IgG responses in infected hosts is expressed by a chromosomal gene.

R B Lefebvre1, G C Perng, R C Johnson.   

Abstract

We report the cloning and characterization of a chromosomal gene from Borrelia burgdorferi expressing an 83-kilodalton protein antigen in Escherichia coli. The antigen reacted strongly with antisera from two human Lyme disease patients. The chromosomal gene was expressed in a 6.5-kilobase-pair ClaI fragment cloned into a variable-reading-frame plasmid vector.

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Year:  1990        PMID： 2380391      PMCID： PMC268016          DOI： 10.1128/jcm.28.7.1673-1675.1990

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  30 in total

1.  Heterogeneity of major proteins in Lyme disease borreliae: a molecular analysis of North American and European isolates.

Authors:  A G Barbour; R A Heiland; T R Howe
Journal:  J Infect Dis       Date:  1985-09       Impact factor: 5.226

2.  In situ enzyme immunodetection of surface or intracellular bacterial antigens using nitrocellulose sheets.

Authors:  J L Guesdon; B Bouges Bocquet; M Débarbouillé; M Hofnung
Journal:  J Immunol Methods       Date:  1985-11-28       Impact factor: 2.303

3.  Antigenic changes of Borrelia burgdorferi as a result of in vitro cultivation.

Authors:  T G Schwan; W Burgdorfer
Journal:  J Infect Dis       Date:  1987-11       Impact factor: 5.226

4.  Isolation of a spirochete from the soft tick, Ornithodoros coriaceus: a possible agent of epizootic bovine abortion.

Authors:  R S Lane; W Burgdorfer; S F Hayes; A G Barbour
Journal:  Science       Date:  1985-10-04       Impact factor: 47.728

5.  Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii.

Authors:  R H Plasterk; M I Simon; A G Barbour
Journal:  Nature       Date:  1985 Nov 21-27       Impact factor: 49.962

6.  Organization of genes encoding two outer membrane proteins of the Lyme disease agent Borrelia burgdorferi within a single transcriptional unit.

Authors:  T R Howe; F W LaQuier; A G Barbour
Journal:  Infect Immun       Date:  1986-10       Impact factor: 3.441

7.  Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

Authors:  J E Craft; D K Fischer; G T Shimamoto; A C Steere
Journal:  J Clin Invest       Date:  1986-10       Impact factor: 14.808

8.  Histopathologic changes in bovine fetuses after repeated reintroduction of a spirochete-like agent into pregnant heifers: association with epizootic bovine abortion.

Authors:  J W Osebold; B I Osburn; R Spezialetti; R B Bushnell; J L Stott
Journal:  Am J Vet Res       Date:  1987-04       Impact factor: 1.156

9.  Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends.

Authors:  A G Barbour; C F Garon
Journal:  Science       Date:  1987-07-24       Impact factor: 47.728

10.  Immunochemical and immunological analysis of European Borrelia burgdorferi strains.

Authors:  B Wilske; V Preac-Mursic; G Schierz; K V Busch
Journal:  Zentralbl Bakteriol Mikrobiol Hyg A       Date:  1986-12
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  26 in total

1.  Laboratory confirmation of Lyme disease.

Authors:  T G Schwan; W J Simpson; P A Rosa
Journal:  Can J Infect Dis       Date:  1991

2.  Further characterization of a potent immunogen and the chromosomal gene encoding it in the Lyme disease agent, Borrelia burgdorferi.

Authors:  G C Perng; R B LeFebvre; R C Johnson
Journal:  Infect Immun       Date:  1991-06       Impact factor: 3.441

3.  Serologic proteome analysis of Borrelia burgdorferi membrane-associated proteins.

Authors:  Andrew J Nowalk; Robert D Gilmore; James A Carroll
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

4.  Borrelia burgdorferi vesicle production occurs via a mechanism independent of immunoglobulin M involvement.

Authors:  R J Shoberg; D D Thomas
Journal:  Infect Immun       Date:  1995-12       Impact factor: 3.441

5.  Interactions between extracellular Borrelia burgdorferi proteins and non-Borrelia-directed immunoglobulin M antibodies.

Authors:  D W Dorward; E D Huguenel; G Davis; C F Garon
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

6.  Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen.

Authors:  W S Probert; R B LeFebvre
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

7.  Specific adherence of Borrelia burgdorferi extracellular vesicles to human endothelial cells in culture.

Authors:  R J Shoberg; D D Thomas
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

8.  Immunodominant proteins of Borrelia burgdorferi, the etiological agent of lyme borreliosis.

Authors:  B Wilske; V Preac-Mursic; R Fuchs; E Soutschek
Journal:  World J Microbiol Biotechnol       Date:  1991-03       Impact factor: 3.312

9.  Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis.

Authors:  L A Magnarelli; E Fikrig; R Berland; J F Anderson; R A Flavell
Journal:  J Clin Microbiol       Date:  1992-12       Impact factor: 5.948

10.  Epitopes shared by unrelated antigens of Borrelia burgdorferi.

Authors:  P Anda; P B Backenson; J L Coleman; J L Benach
Journal:  Infect Immun       Date:  1994-03       Impact factor: 3.441
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