BACKGROUND/AIMS: The rarity of metastatic malignancy in injured liver has been noticed. This meta-analysis evaluates the difference in occurrence of metastatic colorectal cancer in healthy and chronically injured liver. METHODOLOGY: Literature search of occurrence of metastatic colorectal cancer in chronically injured liver opposed to healthy liver was conducted. Chronically injured/damaged liver included cirrhosis, steatosis or fatty liver and infection with Hepatitis virus B or C. RESULTS: A total of 7 retrospective studies between 1992 and 2010 matched the selection criteria with total of 4049 patients. Results suggest significantly lower incidence of colorectal metastasis in chronically injured liver (Pooled odds ratio = 0.260 (95% CI = 0.18 to 0.38); χ² (test odds ratio differs from 1) = 45.90 (df = 1); p <0.0001). CONCLUSIONS: Patients with chronic liver injury have significantly lower occurrence of hepatic metastasis of primary colorectal cancer than the patients with healthy liver.
BACKGROUND/AIMS: The rarity of metastatic malignancy in injured liver has been noticed. This meta-analysis evaluates the difference in occurrence of metastatic colorectal cancer in healthy and chronically injured liver. METHODOLOGY: Literature search of occurrence of metastatic colorectal cancer in chronically injured liver opposed to healthy liver was conducted. Chronically injured/damaged liver included cirrhosis, steatosis or fatty liver and infection with Hepatitis virus B or C. RESULTS: A total of 7 retrospective studies between 1992 and 2010 matched the selection criteria with total of 4049 patients. Results suggest significantly lower incidence of colorectal metastasis in chronically injured liver (Pooled odds ratio = 0.260 (95% CI = 0.18 to 0.38); χ² (test odds ratio differs from 1) = 45.90 (df = 1); p <0.0001). CONCLUSIONS:Patients with chronic liver injury have significantly lower occurrence of hepatic metastasis of primary colorectal cancer than the patients with healthy liver.
Authors: Amanda I Phipps; Michael N Passarelli; Andrew T Chan; Tabitha A Harrison; Jihyoun Jeon; Carolyn M Hutter; Sonja I Berndt; Hermann Brenner; Bette J Caan; Peter T Campbell; Jenny Chang-Claude; Stephen J Chanock; Jeremy P Cheadle; Keith R Curtis; David Duggan; David Fisher; Charles S Fuchs; Manish Gala; Edward L Giovannucci; Richard B Hayes; Michael Hoffmeister; Li Hsu; Eric J Jacobs; Lina Jansen; Richard Kaplan; Elisabeth J Kap; Timothy S Maughan; John D Potter; Robert E Schoen; Daniela Seminara; Martha L Slattery; Hannah West; Emily White; Ulrike Peters; Polly A Newcomb Journal: Carcinogenesis Date: 2015-11-19 Impact factor: 4.944
Authors: Kin Pan Au; Kenneth Siu Ho Chok; Albert Chi Yan Chan; Wing Chiu Dai; Tan To Cheung; Chung Mau Lo Journal: World J Surg Date: 2018-08 Impact factor: 3.352
Authors: Kevin M Waters; Tricia R Cottrell; Sepideh Besharati; Qingfeng Zhu; Robert A Anders Journal: Am J Clin Pathol Date: 2019-01-07 Impact factor: 2.493