Literature DB >> 23800640

[Methylprednisolone- acute spinal cord injury, benefits or risks?].

Maciej Tęsiorowski1, Tomasz Potaczek, Barbara Jasiewicz, Jacek Sapa, Małgorzata Zygmunt.   

Abstract

Methylprednisolone is a synthetic glucocorticoid with a potent and long-acting anti-inflammatory, antiallergic and immunosuppressant. Its mechanism of action of methylprednisolone is the result of many cellular changes. Methylprednisolone is used in many diseases, such as rheumatic diseases, autoimmune diseases, allergic, anaphylactic shock, asthma. Methylprednisolone was also used in patients with spinal cord injury, in order to minimize neurological damage. While in the above mentioned fields of medicine is undeniable role of methylprednisolone, whereas its use in the treatment of traumatic spinal cord injury within the last few years raises a lot of controversy, and in most cases, the side effects of its use outweigh the potential benefits.

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Year:  2013        PMID: 23800640     DOI: 10.5604/17322693.1054873

Source DB:  PubMed          Journal:  Postepy Hig Med Dosw (Online)        ISSN: 0032-5449            Impact factor:   0.270


  4 in total

1.  Atorvastatin activates autophagy and promotes neurological function recovery after spinal cord injury.

Authors:  Shuang Gao; Zhong-Ming Zhang; Zhao-Liang Shen; Kai Gao; Liang Chang; Yue Guo; Zhuo Li; Wei Wang; Ai-Mei Wang
Journal:  Neural Regen Res       Date:  2016-06       Impact factor: 5.135

2.  Methylprednisolone promotes recovery of neurological function after spinal cord injury: association with Wnt/β-catenin signaling pathway activation.

Authors:  Gong-Biao Lu; Fu-Wen Niu; Ying-Chun Zhang; Lin Du; Zhi-Yuan Liang; Yuan Gao; Ting-Zhen Yan; Zhi-Kui Nie; Kai Gao
Journal:  Neural Regen Res       Date:  2016-11       Impact factor: 5.135

3.  Effects of erythropoietin and methylprednisolone on AQP4 expression in astrocytes.

Authors:  Changchao Wang; Youjia Xu; Yadong Huang; Yan Huang
Journal:  Mol Med Rep       Date:  2017-08-22       Impact factor: 2.952

4.  The Conditioned Medium of Lactobacillus rhamnoides GG Regulates Microglia/Macrophage Polarization and Improves Functional Recovery after Spinal Cord Injury in Rats.

Authors:  Fangqi Lin; Baokun Zhang; Qiang Shi; Jiaming Liang; Xin Wang; Xiaofeng Lian; Jianguang Xu
Journal:  Biomed Res Int       Date:  2021-07-10       Impact factor: 3.411

  4 in total

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