OBJECTIVE: The interplay of genetic and nutritional regulation of the insulin-like growth factor-I axis in children is unclear. Therefore, potential gene-nutrient effects on serum levels of the IGF-I axis in a formula feeding trial were studied. DESIGN: European multicenter randomized clinical trial of 1090 term, formula-fed infants assigned to receive cow's milk-based infant and follow-on formulae with lower (LP: 1.25 and 1.6 g/100 mL) or higher (HP: 2.05 and 3.2 g/100 mL) protein contents for the first 12 months of life; a comparison group of 588 breastfed infants (BF) was included. Eight single nucleotide polymorphisms (SNPs) of the IGF-1-(rs6214, rs1520220, rs978458, rs7136446, rs10735380, rs2195239, rs35767, and rs35766) and two of the IGFBP-3-(rs1496495, rs6670) gene were analyzed. Serum levels of total and free IGF-I, IGFBP-3 and the molar ratioIGF-1/IGFBP-3 at age 6 months were regressed on determined SNPs and feeding groups in 501 infants. RESULTS: IGF-1-SNPs rs1520220, rs978458, and rs2195239 significantly increased total-IGF-I and molar-ratio IGF-I/IGFBP-3 by ~1.3 ng/mL and ~1.3 per allele, respectively; compared to LP infants concentration and molar-ratio were increased in HP by ~1.3 ng/mL and ~1.3 and decreased in BF infants by ~0.6 ng/mL and ~0.6, respectively. IGFBP-3 was only affected by the BF group with ~450 ng/mL lower levels than the LP group. No gene-feeding-group interaction was detected for any SNP, even without correction for multiple testing. CONCLUSIONS: Variants of the IGF-1-gene play an important role in regulating serum levels of the IGF-I axis but there is no gene-protein-interaction. The predominant nutritional regulation of IGF-I and IGFBP-3 gives further evidence that higher protein intake contributes to metabolic programming of growth.
RCT Entities:
OBJECTIVE: The interplay of genetic and nutritional regulation of the insulin-like growth factor-I axis in children is unclear. Therefore, potential gene-nutrient effects on serum levels of the IGF-I axis in a formula feeding trial were studied. DESIGN: European multicenter randomized clinical trial of 1090 term, formula-fed infants assigned to receive cow's milk-based infant and follow-on formulae with lower (LP: 1.25 and 1.6 g/100 mL) or higher (HP: 2.05 and 3.2 g/100 mL) protein contents for the first 12 months of life; a comparison group of 588 breastfed infants (BF) was included. Eight single nucleotide polymorphisms (SNPs) of the IGF-1-(rs6214, rs1520220, rs978458, rs7136446, rs10735380, rs2195239, rs35767, and rs35766) and two of the IGFBP-3-(rs1496495, rs6670) gene were analyzed. Serum levels of total and free IGF-I, IGFBP-3 and the molar ratio IGF-1/IGFBP-3 at age 6 months were regressed on determined SNPs and feeding groups in 501 infants. RESULTS:IGF-1-SNPs rs1520220, rs978458, and rs2195239 significantly increased total-IGF-I and molar-ratio IGF-I/IGFBP-3 by ~1.3 ng/mL and ~1.3 per allele, respectively; compared to LPinfants concentration and molar-ratio were increased in HP by ~1.3 ng/mL and ~1.3 and decreased in BF infants by ~0.6 ng/mL and ~0.6, respectively. IGFBP-3 was only affected by the BF group with ~450 ng/mL lower levels than the LP group. No gene-feeding-group interaction was detected for any SNP, even without correction for multiple testing. CONCLUSIONS: Variants of the IGF-1-gene play an important role in regulating serum levels of the IGF-I axis but there is no gene-protein-interaction. The predominant nutritional regulation of IGF-I and IGFBP-3 gives further evidence that higher protein intake contributes to metabolic programming of growth.
Authors: L Damianidi; D Gruszfeld; E Verduci; F Vecchi; A Xhonneux; J-P Langhendries; V Luque; M A Theurich; M Zaragoza-Jordana; B Koletzko; V Grote Journal: Eur J Clin Nutr Date: 2016-06-22 Impact factor: 4.016
Authors: Manja Fleddermann; Hans Demmelmair; Veit Grote; Martin Bidlingmaier; Philipp Grimminger; Maximilian Bielohuby; Berthold Koletzko Journal: Eur J Nutr Date: 2015-11-30 Impact factor: 5.614
Authors: Stefanie M P Kouwenhoven; Manja Fleddermann; Martijn J J Finken; Jos W R Twisk; Eline M van der Beek; Marieke Abrahamse-Berkeveld; Bert J M van de Heijning; Dewi van Harskamp; Johannes B van Goudoever; Berthold V Koletzko Journal: Nutrients Date: 2021-04-01 Impact factor: 5.717
Authors: Hieab H H Adams; Derrek P Hibar; Vincent Chouraki; Jason L Stein; Paul A Nyquist; Miguel E Rentería; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Ashley H Beecham; Neda Jahanshad; Katharina Wittfeld; Sven J Van der Lee; Lucija Abramovic; Saud Alhusaini; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S Aribisala; Nicola J Armstrong; Lavinia Athanasiu; Tomas Axelsson; Alexa Beiser; Manon Bernard; Joshua C Bis; Laura M E Blanken; Susan H Blanton; Marc M Bohlken; Marco P Boks; Janita Bralten; Adam M Brickman; Owen Carmichael; M Mallar Chakravarty; Ganesh Chauhan; Qiang Chen; Christopher R K Ching; Gabriel Cuellar-Partida; Anouk Den Braber; Nhat Trung Doan; Stefan Ehrlich; Irina Filippi; Tian Ge; Sudheer Giddaluru; Aaron L Goldman; Rebecca F Gottesman; Corina U Greven; Oliver Grimm; Michael E Griswold; Tulio Guadalupe; Johanna Hass; Unn K Haukvik; Saima Hilal; Edith Hofer; David Hoehn; Avram J Holmes; Martine Hoogman; Deborah Janowitz; 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