Literature DB >> 23799334

Treatment of food anaphylaxis with traditional Chinese herbal remedies: from mouse model to human clinical trials.

Julie Wang1.   

Abstract

PURPOSE OF REVIEW: To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on traditional Chinese medicine. RECENT
FINDINGS: FAHF-2 has proven to be well tolerated and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after the discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in individuals with food allergies. An ongoing Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges.
SUMMARY: FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23799334      PMCID： PMC4276320          DOI： 10.1097/ACI.0b013e3283615bc4

Source DB:  PubMed          Journal:  Curr Opin Allergy Clin Immunol        ISSN： 1473-6322


  18 in total

1.  Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study.

Authors:  Julie Wang; Sangita P Patil; Nan Yang; Jimmy Ko; Joohee Lee; Sally Noone; Hugh A Sampson; Xiu-Min Li
Journal:  Ann Allergy Asthma Immunol       Date:  2010-07       Impact factor: 6.347

2.  IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene.

Authors:  Jérôme Pène; Laurence Guglielmi; Jean-François Gauchat; Nathalie Harrer; Maximilian Woisetschläger; Vera Boulay; Jean-Michel Fabre; Pascal Demoly; Hans Yssel
Journal:  J Immunol       Date:  2006-10-15       Impact factor: 5.422

3.  Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model.

Authors:  X M Li; T F Zhang; C K Huang; K Srivastava; A A Teper; L Zhang; B H Schofield; H A Sampson
Journal:  J Allergy Clin Immunol       Date:  2001-10       Impact factor: 10.793

4.  The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy.

Authors:  Kamal D Srivastava; Jacob D Kattan; Zhong Mei Zou; Jing Hua Li; Libang Zhang; Sylvan Wallenstein; Joseph Goldfarb; Hugh A Sampson; Xiu-Min Li
Journal:  J Allergy Clin Immunol       Date:  2005-01       Impact factor: 10.793

5.  Efficacy and immunological actions of FAHF-2 in a murine model of multiple food allergies.

Authors:  Kamal D Srivastava; Ludmilla Bardina; Hugh A Sampson; Xiu-Min Li
Journal:  Ann Allergy Asthma Immunol       Date:  2012-05       Impact factor: 6.347

6.  Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula-2 (FAHF-2) on peanut allergy.

Authors:  Jacob D Kattan; Kamal D Srivastava; Zhong Mei Zou; Joseph Goldfarb; Hugh A Sampson; Xiu-Min Li
Journal:  Phytother Res       Date:  2008-05       Impact factor: 5.878

7.  Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells.

Authors:  Kamal D Srivastava; Chunfeng Qu; Tengfei Zhang; Joseph Goldfarb; Hugh A Sampson; Xiu-Min Li
Journal:  J Allergy Clin Immunol       Date:  2009-02       Impact factor: 10.793

8.  Unconventional medicine in the United States. Prevalence, costs, and patterns of use.

Authors:  D M Eisenberg; R C Kessler; C Foster; F E Norlock; D R Calkins; T L Delbanco
Journal:  N Engl J Med       Date:  1993-01-28       Impact factor: 91.245

9.  Induction of tolerance after establishment of peanut allergy by the food allergy herbal formula-2 is associated with up-regulation of interferon-gamma.

Authors:  C Qu; K Srivastava; J Ko; T F Zhang; H A Sampson; X-M Li
Journal:  Clin Exp Allergy       Date:  2007-06       Impact factor: 5.018

10.  Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effect of oleic acid on histamine release.

Authors:  K Tasaka; M Akagi; K Miyoshi; M Mio; T Makino
Journal:  Agents Actions       Date:  1988-04
View more
  4 in total

Review 1.  Engineering the Microbiome: a Novel Approach to Immunotherapy for Allergic and Immune Diseases.

Authors:  Nan Shen; Jose C Clemente
Journal:  Curr Allergy Asthma Rep       Date:  2015-07       Impact factor: 4.806

Review 2.  Food allergy: Insights into etiology, prevention, and treatment provided by murine models.

Authors:  Michiko K Oyoshi; Hans C Oettgen; Talal A Chatila; Raif S Geha; Paul J Bryce
Journal:  J Allergy Clin Immunol       Date:  2014-02       Impact factor: 10.793

3.  Butanol Purified Food Allergy Herbal Formula-2 Has an Immunomodulating Effect ex-vivo in Pediatric Crohn's Disease Subjects.

Authors:  Xin Chen; Joanne Lai; Ying Song; Nan Yang; Sacha Gnjatic; Virginia Gillespie; William Hahn; Ezra Chefitz; Nanci Pittman; Jacqueline Jossen; Keith Benkov; Marla Dubinsky; Xiu-Min Li; David Dunkin
Journal:  Front Med (Lausanne)       Date:  2021-11-29

4.  Exploring the Anti-Pulmonary Fibrosis Mechanism of Jingyin Granule by Network Pharmacology Strategy.

Authors:  De-Wei Zhu; Qun Yu; Mei-Fang Jiang; Dan-Dan Wang; Yun-Hui Shen
Journal:  Front Pharmacol       Date:  2022-02-11       Impact factor: 5.810
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.