INTRODUCTION: Data on the efficacy of hydroxyurea (HU) in Indian children with sickle cell anaemia (SCA) is limited. Hence, we have evaluated the efficacy of fixed low dose HU in Indian children. METHODS: The study cohort consisted of 144 children (<18 years of age) with SCA having severe manifestations (≥ 3 episodes of vasocclusive crisis or blood transfusions, or having ≥ 1 episode of acute chest syndrome or cerebrovascular stroke or sequestration crisis) who were started on fixed low dose HU (10 mg/kg/day). They were followed up for two years and monitored for the hematological and clinical efficacy and safety. RESULTS: There was significant increase in the fetal hemoglobin level (HbF%), total hemoglobin and mean corpuscular volume. Vasoocclusive crises, blood transfusions, acute chest syndrome, sequestration crises and hospitalizations decreased significantly. Baseline HbF% had significant positive correlation with HbF% at 24 months. There was significant negative correlation between baseline HbF% and change in HbF% from baseline to 24 months. No significant correlation was found between HbF% at baseline and clinical event rates per year after HU. No major adverse events occurred during the study period. CONCLUSIONS: Fixed low dose HU is effective and safe in Indian children with SCA.
INTRODUCTION: Data on the efficacy of hydroxyurea (HU) in Indian children with sickle cell anaemia (SCA) is limited. Hence, we have evaluated the efficacy of fixed low dose HU in Indian children. METHODS: The study cohort consisted of 144 children (<18 years of age) with SCA having severe manifestations (≥ 3 episodes of vasocclusive crisis or blood transfusions, or having ≥ 1 episode of acute chest syndrome or cerebrovascular stroke or sequestration crisis) who were started on fixed low dose HU (10 mg/kg/day). They were followed up for two years and monitored for the hematological and clinical efficacy and safety. RESULTS: There was significant increase in the fetal hemoglobin level (HbF%), total hemoglobin and mean corpuscular volume. Vasoocclusive crises, blood transfusions, acute chest syndrome, sequestration crises and hospitalizations decreased significantly. Baseline HbF% had significant positive correlation with HbF% at 24 months. There was significant negative correlation between baseline HbF% and change in HbF% from baseline to 24 months. No significant correlation was found between HbF% at baseline and clinical event rates per year after HU. No major adverse events occurred during the study period. CONCLUSIONS: Fixed low dose HU is effective and safe in Indian children with SCA.
Authors: Patrick T McGann; Thomas N Williams; Peter Olupot-Olupot; George A Tomlinson; Adam Lane; José Luís Reis da Fonseca; Robert Kitenge; George Mochamah; Ham Wabwire; Susan Stuber; Thad A Howard; Kathryn McElhinney; Banu Aygun; Teresa Latham; Brígida Santos; Léon Tshilolo; Russell E Ware Journal: Am J Hematol Date: 2018-01-27 Impact factor: 10.047
Authors: Joacy G Mathias; Vikki G Nolan; Meghan Meadows-Taylor; L Ashley Robinson; Kristen E Howell; James G Gurney; Jane S Hankins; Winfred C Wang; Jeremie H Estepp; Matthew P Smeltzer Journal: EJHaem Date: 2020-04-26
Authors: Titilola S Akingbola; Bamidele O Tayo; Chinedu A Ezekekwu; Omowunmi Sonubi; Xu Zhang; Santosh L Saraf; Robert Molokie; Lewis L Hsu; Jin Han; Richard S Cooper; Victor R Gordeuk Journal: Am J Hematol Date: 2019-02-06 Impact factor: 10.047