Literature DB >> 23798474

Diffuse lung disease in children: summary of a scientific conference.

Aaron Hamvas1, Robin Deterding, William E Balch, David A Schwartz, Kurt H Albertine, Jeffrey A Whitsett, Wellington V Cardoso, Darrell N Kotton, Stella Kourembanas, James S Hagood.   

Abstract

A multi-disciplinary scientific conference focused on diffuse and interstitial lung diseases in children was held in La Jolla, CA in June 2012. The conference brought together clinicians (including Pediatric and Adult Pulmonologists, Neonatologists, Pathologists, and Radiologists), clinical researchers, basic scientists, government agency representatives, patient advocates, as well as children affected by diffuse lung disease (DLD) and their families, to review recent scientific developments and emerging concepts in the pathophysiology of childhood DLD. Invited speakers discussed translational approaches, including genetics and proteomics, epigenetics and epigenomics, models of DLD, including animal models and induced pluripotent stem cells, and regenerative medicine approaches. The presentations of the invited speakers are summarized here.
© 2013 Wiley Periodicals, Inc.

Entities:  

Keywords:  childhood interstitial lung disease; diffuse lung disease; epigenetics; genetics; stem cell

Mesh:

Substances:

Year:  2013        PMID: 23798474      PMCID: PMC4145861          DOI: 10.1002/ppul.22805

Source DB:  PubMed          Journal:  Pediatr Pulmonol        ISSN: 1099-0496


  53 in total

Review 1.  Integrating 'omic' information: a bridge between genomics and systems biology.

Authors:  Hui Ge; Albertha J M Walhout; Marc Vidal
Journal:  Trends Genet       Date:  2003-10       Impact factor: 11.639

2.  Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome.

Authors:  Jennifer A Wambach; Daniel J Wegner; Kelcey Depass; Hillary Heins; Todd E Druley; Robi D Mitra; Ping An; Qunyuan Zhang; Lawrence M Nogee; F Sessions Cole; Aaron Hamvas
Journal:  Pediatrics       Date:  2012-11-19       Impact factor: 7.124

3.  NKX2-1 mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in "Brain-Lung-Thyroid Syndrome".

Authors:  Loïc Guillot; Aurore Carré; Gabor Szinnai; Mireille Castanet; Elodie Tron; Francis Jaubert; Isabelle Broutin; François Counil; Delphine Feldmann; Annick Clement; Michel Polak; Ralph Epaud
Journal:  Hum Mutat       Date:  2010-02       Impact factor: 4.878

Review 4.  Emergent properties of proteostasis in managing cystic fibrosis.

Authors:  William E Balch; Daniela M Roth; Darren M Hutt
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-02-01       Impact factor: 10.005

5.  Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency.

Authors:  Heiko Krude; Barbara Schütz; Heike Biebermann; Arpad von Moers; Dirk Schnabel; Heidi Neitzel; Holger Tönnies; Dagmar Weise; Antony Lafferty; Siegfried Schwarz; Mario DeFelice; Andreas von Deimling; Frank van Landeghem; Roberto DiLauro; Annette Grüters
Journal:  J Clin Invest       Date:  2002-02       Impact factor: 14.808

6.  A common mutation in the surfactant protein C gene associated with lung disease.

Authors:  H Scott Cameron; Marco Somaschini; Paola Carrera; Aaron Hamvas; Jeffrey A Whitsett; Susan E Wert; Gail Deutsch; Lawrence M Nogee
Journal:  J Pediatr       Date:  2005-03       Impact factor: 4.406

7.  Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.

Authors:  William D Hardie; Timothy D Le Cras; Kenny Jiang; Jay W Tichelaar; Mohamad Azhar; Thomas R Korfhagen
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2003-12-05       Impact factor: 5.464

8.  Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate.

Authors:  Mitsuru Morimoto; Zhenyi Liu; Hui-Teng Cheng; Niki Winters; David Bader; Raphael Kopan
Journal:  J Cell Sci       Date:  2010-01-15       Impact factor: 5.285

9.  Five new TTF1/NKX2.1 mutations in brain-lung-thyroid syndrome: rescue by PAX8 synergism in one case.

Authors:  Aurore Carré; Gabor Szinnai; Mireille Castanet; Sylvia Sura-Trueba; Elodie Tron; Isabelle Broutin-L'Hermite; Pascal Barat; Cyril Goizet; Didier Lacombe; Marie-Laure Moutard; Christine Raybaud; Catherine Raynaud-Ravni; Serge Romana; Hubert Ythier; Juliane Léger; Michel Polak
Journal:  Hum Mol Genet       Date:  2009-03-31       Impact factor: 6.150

10.  Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension.

Authors:  Georg Hansmann; Angeles Fernandez-Gonzalez; Muhammad Aslam; Sally H Vitali; Thomas Martin; S Alex Mitsialis; Stella Kourembanas
Journal:  Pulm Circ       Date:  2012 Apr-Jun       Impact factor: 3.017

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  5 in total

Review 1.  Beyond the genome: epigenetic mechanisms in lung remodeling.

Authors:  James S Hagood
Journal:  Physiology (Bethesda)       Date:  2014-05

Review 2.  Pediatric lung transplantation: indications and outcomes.

Authors:  Stephen Kirkby; Don Hayes
Journal:  J Thorac Dis       Date:  2014-08       Impact factor: 2.895

Review 3.  Epigenetic contributions to the developmental origins of adult lung disease.

Authors:  Lisa A Joss-Moore; Robert H Lane; Kurt H Albertine
Journal:  Biochem Cell Biol       Date:  2014-10-13       Impact factor: 3.626

Review 4.  The proteomics of lung injury in childhood: challenges and opportunities.

Authors:  Prue M Pereira-Fantini; David G Tingay
Journal:  Clin Proteomics       Date:  2016-02-29       Impact factor: 3.988

Review 5.  Genomics, microbiomics, proteomics, and metabolomics in bronchopulmonary dysplasia.

Authors:  Charitharth Vivek Lal; Vineet Bhandari; Namasivayam Ambalavanan
Journal:  Semin Perinatol       Date:  2018-10-02       Impact factor: 3.300

  5 in total

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