Literature DB >> 2379832

Sister chromatid exchange in methotrexate resistant and sensitive C3H10T1/2 mouse cells.

M Zamboni1, E Privitera, G Mosna, A Ghidoni.   

Abstract

Sister chromatid exchange (SCE) induction by methotrexate (MTX) was analyzed in C3H10T1/2 clone 8 mouse cells and in two MTX-resistant subclones with numerous double minute chromosomes (DM) present in the majority of cells. Significantly higher SCE levels were found, as expected, in sensitive cells after treatments with 10(-2) or 10(-5) M MTX but not in resistant cells permanently growing in the presence of a high concentration of MTX (2 x 10(-3) M) and characterized by a markedly lower cell cycle replication index (R.I.), i.e. in conditions that are known to otherwise favour SCE induction. These observations suggest, for the MTX-resistant cells under study, the existence of conditions limiting SCE formation.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2379832     DOI： 10.1007/bf00137330

Source DB:  PubMed          Journal:  Genetica        ISSN： 0016-6707            Impact factor:   1.082


  26 in total

1.  Sister chromatid exchange studies for monitoring DNA damage and repair capacity after cytostatics in vitro and in lymphocytes of leukaemic patients under cytostatic therapy.

Authors:  T Raposa
Journal:  Mutat Res       Date:  1978-05       Impact factor: 2.433

2.  Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.

Authors:  C A Reznikoff; D W Brankow; C Heidelberger
Journal:  Cancer Res       Date:  1973-12       Impact factor: 12.701

3.  Aging and sister chromatid exchange. VIII. Effect of the aging environment on sister chromatid exchange induction and cell cycle kinetics in Ehrlich ascites tumor cells. A brief note.

Authors:  E L Schneider; J Lewis
Journal:  Mech Ageing Dev       Date:  1981-12       Impact factor: 5.432

4.  Inhibition of protein synthesis antagonizes induction of sister-chromatid exchanges by exogenous agents.

Authors:  A Sono; K Sakaguchi
Journal:  Mutat Res       Date:  1981-01       Impact factor: 2.433

5.  Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

Authors:  F W Alt; R E Kellems; J R Bertino; R T Schimke
Journal:  J Biol Chem       Date:  1978-03-10       Impact factor: 5.157

6.  Amethopterin resistance in clonal lines of L1210 mouse leukemia: some associated biologic and biochemical alterations.

Authors:  A Hoshino; A M Albrecht; J L Biedler; D J Hutchison
Journal:  Cancer Res       Date:  1966-07       Impact factor: 12.701

7.  Sister chromatid exchanges, indices of human chromosome damage and repair: detection by fluorescence and induction by mitomycin C.

Authors:  S A Latt
Journal:  Proc Natl Acad Sci U S A       Date:  1974-08       Impact factor: 11.205

8.  Risk of therapy-related leukaemia and preleukaemia after Hodgkin's disease. Relation to age, cumulative dose of alkylating agents, and time from chemotherapy.

Authors:  J Pedersen-Bjergaard; L Specht; S O Larsen; J Ersbøll; J Struck; M M Hansen; H H Hansen; N I Nissen
Journal:  Lancet       Date:  1987-07-11       Impact factor: 79.321

9.  Novel submicroscopic extrachromosomal elements containing amplified genes in human cells.

Authors:  B J Maurer; E Lai; B A Hamkalo; L Hood; G Attardi
Journal:  Nature       Date:  1987 Jun 4-10       Impact factor: 49.962

10.  Second acute leukemia and other malignancies following treatment for Hodgkin's disease.

Authors:  P Valagussa; A Santoro; F Fossati-Bellani; A Banfi; G Bonadonna
Journal:  J Clin Oncol       Date:  1986-06       Impact factor: 44.544
View more
  1 in total

1.  Association between sister chromatid exchange and double minute chromosomes in human tumor cells.

Authors:  Jie Xu; Peng Liu; Xiangning Meng; Jing Bai; Songbin Fu; Rongwei Guan; Wenjing Sun
Journal:  Mol Cytogenet       Date:  2015-11-19       Impact factor: 2.009
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.