BACKGROUND: The goal of the present study was to determine knee extensor muscle strength (KEMS) and degree of renal dysfunction associated with an exercise capacity of ≥5 metabolic equivalents (METs) in male chronic heart failure (CHF) patients with chronic kidney disease (CKD). METHODS: In this cross-sectional study of 75 male CHF patients with CKD (65.3 ± 11.6 years), we measured clinical characteristics, peak [Formula: see text], estimated glomerular filtration rate (eGFR), and KEMS. Patients were divided into two groups by exercise capacity: ≥5 METs group (n = 41) and <5 METs group (n = 34). Cutoff values for KEMS and eGFR resulting in an exercise capacity of ≥5 METs were selected with ROC curves. Patients were divided into four groups according to cutoff values, and numbers of patients attaining an exercise capacity of ≥5 METs were compared between groups. RESULTS: Age was significantly higher although eGFR, Hb, and KEMS were lower in the <5 METs versus ≥5 METs group (P < 0.001). Multiple logistic regression analysis revealed a positive significant relation between KEMS and eGFR and exercise capacity of ≥5 METs. Exercise capacity of ≥5 METs was associated with KEMS of approximately 1.69 Nm/kg and an eGFR of 45.7 mL/min/1.73 m(2). The number of patients attaining an exercise capacity of ≥5 METs in the patients who did not reach both cutoff values was significantly lower than that in any other patients (P < 0.001). CONCLUSION: KEMS and eGFR may be useful indices for predicting attainment of exercise capacity of ≥5 METs in male CHF patients with CKD.
BACKGROUND: The goal of the present study was to determine knee extensor muscle strength (KEMS) and degree of renal dysfunction associated with an exercise capacity of ≥5 metabolic equivalents (METs) in male chronic heart failure (CHF) patients with chronic kidney disease (CKD). METHODS: In this cross-sectional study of 75 male CHFpatients with CKD (65.3 ± 11.6 years), we measured clinical characteristics, peak [Formula: see text], estimated glomerular filtration rate (eGFR), and KEMS. Patients were divided into two groups by exercise capacity: ≥5 METs group (n = 41) and <5 METs group (n = 34). Cutoff values for KEMS and eGFR resulting in an exercise capacity of ≥5 METs were selected with ROC curves. Patients were divided into four groups according to cutoff values, and numbers of patients attaining an exercise capacity of ≥5 METs were compared between groups. RESULTS: Age was significantly higher although eGFR, Hb, and KEMS were lower in the <5 METs versus ≥5 METs group (P < 0.001). Multiple logistic regression analysis revealed a positive significant relation between KEMS and eGFR and exercise capacity of ≥5 METs. Exercise capacity of ≥5 METs was associated with KEMS of approximately 1.69 Nm/kg and an eGFR of 45.7 mL/min/1.73 m(2). The number of patients attaining an exercise capacity of ≥5 METs in the patients who did not reach both cutoff values was significantly lower than that in any other patients (P < 0.001). CONCLUSION: KEMS and eGFR may be useful indices for predicting attainment of exercise capacity of ≥5 METs in male CHFpatients with CKD.
Authors: D Harrington; S D Anker; T P Chua; K M Webb-Peploe; P P Ponikowski; P A Poole-Wilson; A J Coats Journal: J Am Coll Cardiol Date: 1997-12 Impact factor: 24.094
Authors: H L Hillege; A R Girbes; P J de Kam; F Boomsma; D de Zeeuw; A Charlesworth; J R Hampton; D J van Veldhuisen Journal: Circulation Date: 2000-07-11 Impact factor: 29.690
Authors: Todd M Manini; Marjolein Visser; Seok Won-Park; Kushang V Patel; Elsa S Strotmeyer; Hepei Chen; Bret Goodpaster; Nathalie De Rekeneire; Anne B Newman; Eleanor M Simonsick; Stephen B Kritchevsky; Kathy Ryder; Ann V Schwartz; Tamara B Harris Journal: J Am Geriatr Soc Date: 2007-03 Impact factor: 5.562