| Literature DB >> 23796872 |
Yi-Chia Wei1, Chi-Hung Liu, Jainn-Jim Lin, Kun-Ju Lin, Ko-Lun Huang, Tsong-Hai Lee, Yeu-Jhy Chang, Tsung-I Peng, Kuang-Lin Lin, Ting-Yu Chang, Chien-Hung Chang, Hung-Chou Kuo, Kuo-Hsuan Chang, Mei-Yun Cheng, Chin-Chang Huang.
Abstract
Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is an anti-neuronal surface antigen autoimmune encephalitis that is rarely reported. Our study evaluated the first known patient who developed anti-AMPA receptor encephalitis during pregnancy. Initial brain MRI revealed bilateral limbic encephalitis. However, rapid brain atrophy on MRI with extensive hypometabolism of cerebral cortices, caudate nuclei and brain stem hypoperfusion on (18)F-FDG PET developed when clinically progressed. IgG index of serial CSF studies reflected the clinical improvements after plasmapheresis and plasma exchange. The clinical spectrum of anti-AMPA receptor encephalitis may be expanded from limited limbic involvement to extended central nervous system.Entities:
Keywords: AMPA; Anti-glutamate receptor; Brain atrophy; Encephalitis; Eosinophilic meningoencephalitis
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Year: 2013 PMID： 23796872 DOI： 10.1016/j.jneuroim.2013.05.011
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478