Literature DB >> 2379544

A novel mast cell growth factor (MCGF-3) produced by marrow-adherent cells that synergizes with interleukin 3 and interleukin 4.

H S Boswell1, D Y Mochizuki, G S Burgess, S Gillis, E B Walker, D Anderson, D E Williams.   

Abstract

A clonal marrow-adherent stromal cell line, +/+-1 LDA11, was derived and found to produce hemopoietic stimulatory activity for an interleukin 3 (IL-3)-dependent mast cell line, NFS/N1. This factor-dependent mast cell line displayed restricted growth factor responsiveness to only IL-3, interleukin 4 (IL-4), and the stromal cell-produced factor. The factor produced by stromal cells was distinguished from IL-3 and IL-4 and was characterized biochemically. This factor appears to be a novel mast cell growth factor (MCGF-3) capable of synergizing with IL-3 and IL-4. It may have broader reactivity in hemopoiesis than simply IL-3-dependent mast cells, and it may prove relevant to stromal cell-mediated hemopoiesis.

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Year:  1990        PMID： 2379544

Source DB:  PubMed          Journal:  Exp Hematol        ISSN： 0301-472X            Impact factor:   3.084


  7 in total

1.  Cytokines, hematopoiesis, osteoclastogenesis, and estrogens.

Authors:  S C Manolagas; R L Jilka
Journal:  Calcif Tissue Int       Date:  1992-03       Impact factor: 4.333

2.  The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

Authors:  R Rottapel; M Reedijk; D E Williams; S D Lyman; D M Anderson; T Pawson; A Bernstein
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

3.  17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.

Authors:  G Girasole; R L Jilka; G Passeri; S Boswell; G Boder; D C Williams; S C Manolagas
Journal:  J Clin Invest       Date:  1992-03       Impact factor: 14.808

4.  Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation.

Authors:  S E Jacobsen; F W Ruscetti; C M Dubois; J R Keller
Journal:  J Exp Med       Date:  1992-06-01       Impact factor: 14.307

5.  Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.

Authors:  T Bellido; N Stahl; T J Farruggella; V Borba; G D Yancopoulos; S C Manolagas
Journal:  J Clin Invest       Date:  1996-01-15       Impact factor: 14.808

6.  Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase.

Authors:  T Ito; R Jagus; W S May
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

7.  Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.

Authors:  E Keshet; S D Lyman; D E Williams; D M Anderson; N A Jenkins; N G Copeland; L F Parada
Journal:  EMBO J       Date:  1991-09       Impact factor: 11.598
  7 in total

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