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Literature DB >> 2379539

The metabolic effects of aspirin in fasting and fed subjects: relevance to the aetiology of Reye's syndrome.

F M Williams¹, R E Ferner, M Graham, P G Blain, K G Alberti, M D Rawlins.

Abstract

As a possible model for the mechanism of precipitation of Reye's Syndrome in children the metabolic effects of oral aspirin were studied in normal subjects in the fasted and fed states, to determine whether aspirin altered fatty acid oxidation. Starvation increased blood 3-hydroxybutyrate concentrations, but aspirin had no effect on this or other metabolite concentrations in either the fasted or fed states.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2379539 DOI： 10.1007/bf02336695

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

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References

14 in total

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Authors: R D REYE; G MORGAN; J BARAL
Journal: Lancet Date: 1963-10-12 Impact factor: 79.321

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Authors: N Gerber; R G Dickinson; R C Harland; R K Lynn; L D Houghton; J I Antonias; J C Schimschock
Journal: J Pediatr Date: 1979-07 Impact factor: 4.406

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Authors: K M Starko; F G Mullick
Journal: Lancet Date: 1983-02-12 Impact factor: 79.321

The metabolic effects of aspirin in fasting and fed subjects: relevance to the aetiology of Reye's syndrome.

1. ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA. A DISEASE ENTITY IN CHILDHOOD.

2. Reye-like syndrome associated with valproic acid therapy.

3. Hepatic and cerebral pathology findings in children with fatal salicylate intoxication: further evidence for a causal relation between salicylate and Reye's syndrome.

4. Aspirin as a risk factor in Reye's syndrome.

5. Reye's syndrome and medication use.

6. Public Health Service study on Reye's syndrome and medications. Report of the pilot phase.

7. Aspirin metabolism and efficacy in postoperative dental pain.

8. The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats.

9. Dopamine blockade inhibits starvation ketosis in man.

10. Influence of valproic acid on hepatic carbohydrate and lipid metabolism.