Literature DB >> 23794491

Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.

Christoph Arkona1, Jörg Rademann.   

Abstract

Entities:  

Keywords:  bioorthogonality; irreversible inhibitors; proteases; protein-templated reactions; ubiquitin

Mesh：

Substances：

Year:  2013        PMID： 23794491     DOI： 10.1002/anie.201303544

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


× No keyword cloud information.
  5 in total

1.  Cyclopropenone-caged Sondheimer diyne (dibenzo[a,e]cyclooctadiyne): a photoactivatable linchpin for efficient SPAAC crosslinking.

Authors:  Dewey A Sutton; Seok-Ho Yu; Richard Steet; Vladimir V Popik
Journal:  Chem Commun (Camb)       Date:  2015-11-05       Impact factor: 6.222

Review 2.  Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.

Authors:  David S Hewings; John A Flygare; Matthew Bogyo; Ingrid E Wertz
Journal:  FEBS J       Date:  2017-03-10       Impact factor: 5.542

Review 3.  Flipping the Switch: Innovations in Inducible Probes for Protein Profiling.

Authors:  Sean M McKenna; Ellen M Fay; Joanna F McGouran
Journal:  ACS Chem Biol       Date:  2021-11-15       Impact factor: 5.100

4.  Sequential "click" - "photo-click" cross-linker for catalyst-free ligation of azide-tagged substrates.

Authors:  Selvanathan Arumugam; Vladimir V Popik
Journal:  J Org Chem       Date:  2014-02-28       Impact factor: 4.354

5.  The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K.

Authors:  Elma Mons; Ineke D C Jansen; Jure Loboda; Bjorn R van Doodewaerd; Jill Hermans; Martijn Verdoes; Constant A A van Boeckel; Peter A van Veelen; Boris Turk; Dusan Turk; Huib Ovaa
Journal:  J Am Chem Soc       Date:  2019-02-14       Impact factor: 15.419
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.