BACKGROUND: Normal intrauterine conditions are essential to normal brain growth and development; premature birth and growth restriction can interrupt brain maturation. Maturation processes can be studied using diffusion tensor imaging. OBJECTIVE: The aim of this study was to use tract-based spatial statistics to assess the effect that early postnatal growth from birth to 40 gestational weeks has on brain white matter maturation. MATERIALS AND METHODS: A total of 36 preterm infants were accepted in the study. Postnatal growth was assessed by weight, length and head circumference. Birth weight z-score and gestational age were used as confounding covariates. RESULTS: Head circumference catch-up growth was associated with less mature diffusion parameters (P < 0.05). No significant associations were observed between weight or length growth and diffusion parameters. CONCLUSION: Growth-restricted infants seem to have delayed brain maturation that is not fully compensated at term, despite catch-up growth.
BACKGROUND: Normal intrauterine conditions are essential to normal brain growth and development; premature birth and growth restriction can interrupt brain maturation. Maturation processes can be studied using diffusion tensor imaging. OBJECTIVE: The aim of this study was to use tract-based spatial statistics to assess the effect that early postnatal growth from birth to 40 gestational weeks has on brain white matter maturation. MATERIALS AND METHODS: A total of 36 preterm infants were accepted in the study. Postnatal growth was assessed by weight, length and head circumference. Birth weight z-score and gestational age were used as confounding covariates. RESULTS: Head circumference catch-up growth was associated with less mature diffusion parameters (P < 0.05). No significant associations were observed between weight or length growth and diffusion parameters. CONCLUSION: Growth-restricted infants seem to have delayed brain maturation that is not fully compensated at term, despite catch-up growth.
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: Virva Lepomäki; Jaakko Matomäki; Helena Lapinleimu; Liisa Lehtonen; Leena Haataja; Markku Komu; Riitta Parkkola Journal: Pediatr Radiol Date: 2012-11-18
Authors: Savannah C Partridge; Pratik Mukherjee; Roland G Henry; Steven P Miller; Jeffrey I Berman; Hua Jin; Ying Lu; Orit A Glenn; Donna M Ferriero; A James Barkovich; Daniel B Vigneron Journal: Neuroimage Date: 2004-07 Impact factor: 6.556
Authors: Anna Nyman; Tapio Korhonen; Petriina Munck; Riitta Parkkola; Liisa Lehtonen; Leena Haataja Journal: Pediatr Res Date: 2017-05-24 Impact factor: 3.756