Literature DB >> 23793793

Recent advances in the Willgerodt-Kindler reaction.

Daniel L Priebbenow1, Carsten Bolm.   

Abstract

The Willgerodt-Kindler reaction has, in recent years, received limited attention and application in synthetic organic chemistry. With the advent of new technology such as microwave-assisted heating, several new, high-yielding, practical, and more environmentally friendly reaction protocols have been developed. This review aims to once again draw attention to this relatively underutilised process by highlighting the recent developments in the Willgerodt-Kindler reaction in the synthesis of (thio)amides, carboxylic acids, and heterocycles.

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Year:  2013        PMID： 23793793     DOI： 10.1039/c3cs60154d

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  8 in total

1.  Synthesis of primary N-arylthioglyoxamides from anilines, elemental sulfur and primary C-H bonds in acetophenones.

Authors:  Khoa M Tran; Nguyen H K Nguyen; Thuy T Bui; Tuong A To; Nam T S Phan; Ha V Le; Tung T Nguyen
Journal:  RSC Adv       Date:  2020-12-18       Impact factor: 4.036

2.  Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source.

Authors:  Penghui Ni; Jing Tan; Rong Li; Huawen Huang; Feng Zhang; Guo-Jun Deng
Journal:  RSC Adv       Date:  2020-01-23       Impact factor: 3.361

3.  Microwave-assisted iodine-catalyzed oxidative coupling of dibenzyl(difurfuryl)disulfides with amines: a rapid and efficient protocol for thioamides.

Authors:  Jinyang Chen; Lan Mei; Jialing Liu; Chuntao Zhong; Binfang Yuan; Qiang Li
Journal:  RSC Adv       Date:  2019-09-10       Impact factor: 4.036

4.  New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur.

Authors:  Tien V Huynh; Khang V Doan; Ngoc T K Luong; Duyen T P Nguyen; Son H Doan; Tung T Nguyen; Nam T S Phan
Journal:  RSC Adv       Date:  2020-05-14       Impact factor: 3.361

5.  Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer.

Authors:  Omar A El-Khouly; Morkos A Henen; Magda A-A El-Sayed; Shahenda M El-Messery
Journal:  Sci Rep       Date:  2022-10-12       Impact factor: 4.996

6.  Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists.

Authors:  Alexey Lukin; Anna Bakholdina; Mikhail Chudinov; Oleksandra Onopchenko; Elena Zhuravel; Sergey Zozulya; Maxim Gureev; Mikhail Krasavin
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

7.  Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides.

Authors:  Weibing Liu; Cui Chen; Hailing Liu
Journal:  Beilstein J Org Chem       Date:  2015-09-23       Impact factor: 2.883

8.  Palladium-catalyzed Suzuki-Miyaura coupling of thioureas or thioamides.

Authors:  Shaoyu Mai; Wendong Li; Xue Li; Yingwei Zhao; Qiuling Song
Journal:  Nat Commun       Date:  2019-12-13       Impact factor: 14.919
  8 in total

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