Aman Sharma1, Ravinder Kaur Sachdeva2, Mahendra Kumar3, Ritu Nehra4, Monika Nakra2, Deborah Jones5. 1. Department of Internal Medicine, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India amansharma74@yahoo.com. 2. Department of Internal Medicine, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India. 3. Department of Psychiatry and Neurosciences, Molecular Neuroendocrinology/Neurotransmitters Laboratories, University of Miami Miller School of Medicine, Miami, FL, USA. 4. Department of Psychiatry, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India. 5. Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Abstract
BACKGROUND: The effects of previous alcohol abuse on antiretroviral therapy (ART) adherence have been less studied. MATERIALS AND METHODOLOGY: Participants were randomized to a 3-month group intervention or an individual-enhanced standard-of-care condition and assessed over 6 months. Individual assessment at baseline, 3, and 6 months was done; interviews included lifetime history of problematic alcohol use. RESULTS: A total of 80 HIV-positive individuals on ART were recruited. In all, 35% of participants reported a history of problematic alcohol use, 37% had a detectable viral load, 55% were nonadherent, and 24% reporting skipping medication in the previous 3 months. There was no association between a history of problematic use and an adherence at any time point, that is, at baseline (t = -.7, P = .47), midpoint (t = -.39, P = .69), and 6-month follow-up (t = -1.2, P = .23). CONCLUSION: Results suggest that a history of problematic alcohol use may not impact ART adherence.
RCT Entities:
BACKGROUND: The effects of previous alcohol abuse on antiretroviral therapy (ART) adherence have been less studied. MATERIALS AND METHODOLOGY:Participants were randomized to a 3-month group intervention or an individual-enhanced standard-of-care condition and assessed over 6 months. Individual assessment at baseline, 3, and 6 months was done; interviews included lifetime history of problematic alcohol use. RESULTS: A total of 80 HIV-positive individuals on ART were recruited. In all, 35% of participants reported a history of problematic alcohol use, 37% had a detectable viral load, 55% were nonadherent, and 24% reporting skipping medication in the previous 3 months. There was no association between a history of problematic use and an adherence at any time point, that is, at baseline (t = -.7, P = .47), midpoint (t = -.39, P = .69), and 6-month follow-up (t = -1.2, P = .23). CONCLUSION: Results suggest that a history of problematic alcohol use may not impact ART adherence.
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