| Literature DB >> 23791886 |
Kashmira Kulkarni-Datar1, Sandra Orsulic, Rosemary Foster, Bo R Rueda.
Abstract
Development of recurrent platinum resistant disease following chemotherapy presents a challenge in managing ovarian cancer. Using tumors derived from genetically defined mouse ovarian cancer cells, we investigated the stem cell properties of residual cells post-chemotherapy. Utilizing CD133 and Sca-1 as markers of candidate tumor initiating cells (TIC), we determined that the relative levels of CD133+ and Sca-1+ cells were unaltered following chemotherapy. CD133+ and Sca-1+ cells exhibited increased stem cell-related gene expression, were enriched in G0/G1-early S phase and exhibited increased tumor initiating capacity, giving rise to heterogeneous tumors. Our findings suggest that residual TICs may contribute to recurrent disease.Entities:
Keywords: CD133 cells; Ovarian cancer tumor initiating cells; Sca-1 cells
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Year: 2013 PMID： 23791886 DOI： 10.1016/j.canlet.2013.06.014
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679