| Literature DB >> 23791853 |
Jiping Liu1, Liang Feng, Dongying Ma, Minghua Zhang, Junfei Gu, Shuyuan Wang, Qiang Fu, Yu Song, Zhou Lan, Rong Qu, Shiping Ma.
Abstract
Diabetic encephalopathy (DE) has been characterized by the impaired cognition and the abnormalities of neurochemistry and neurostructure. The study was conducted to evaluate the neuroprotective effect of paeonol on STZ-induced DE rats. Paeonol of 25, 50, 100mg/kg (p.o.) could decrease the latency time and path length, and enhance significantly the spent time in the target quadrant and platform crossings in Morris water maze test. The treatment with paeonol could also increase significantly Na(+)-K(+)-ATP enzyme and ChAT activities, as well as decreasing significantly AchE activity in hippocampal tissue. Immunohistochemistry and TUNEL staining showed that paeonol could attenuate apoptosis of neurons and caspase 3 expression, improve two neurotrophic factors BDNF and IGF expressions, and also ameliorate Aβ deposition in the hippocampus and cerebral cortex. In conclusion, the present study demonstrated diabetic rats treated with paeonol could ameliorate the cognition deficits. These findings indicated paeonol might act as a beneficial agent for the prevention and treatment of DE.Entities:
Keywords: AChE; Anti-apoptosis; Aβ; BDNF; ChAT; Cognition deficits; DE; Diabetic encephalopathy; HGF; IGF; Na(+)-K(+)-ATPase; Na(+)-K(+)-adenosine triphosphatase; Neuropathological changes; Paeonol; STZ; acetylcholinesterase; amyloid beta; brain derived neurotrophic factor; choline acetyltransferase; diabetic encephalopathy; high-glucose-fat diet; insulin-like growth factors; streptozotocin; β-amyloid
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Year: 2013 PMID： 23791853 DOI： 10.1016/j.neulet.2013.06.002
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046