Tony Shang-Chuan Chen1, Alexander Incani2, Tom C Butler3, Karl Poon3, Jinlin Fu3, Michael Savage3, Margaret Dahl3, Donna E Callow3, Daniel Colburn4, Chris Hammett4, Darren L Walters2. 1. Department of Cardiology, The Prince Charles Hospital, Rode Road, Chermside, QLD 4032, Australia; Prince of Wales Clinical School, University of New South Wales (UNSW) Medicine, Australia. Electronic address: tony.chen@unsw.edu.au. 2. Department of Cardiology, The Prince Charles Hospital, Rode Road, Chermside, QLD 4032, Australia; School of Medicine, University of Queensland, Australia. 3. Department of Cardiology, The Prince Charles Hospital, Rode Road, Chermside, QLD 4032, Australia. 4. Department of Cardiology, Royal Brisbane and Women's Hospital, Cnr Butterfield Street and Bowen Bridge Road, Herston, QLD 4029, Australia.
Abstract
BACKGROUND: There is little data regarding the demographic profile of young (<45 years) Australian acute coronary syndrome patients. The aim of this study was to compare baseline characteristics, risk factor profile and outcomes of young patients compared with their older counterparts referred to two metropolitan Queensland hospitals. METHODS: Over a four-year period, data on acute coronary syndrome patients referred to The Prince Charles and Royal Brisbane Hospitals were retrospectively analysed. Three major groups were identified: <45 years, 45-60 years and those >60 years. Age, sex, body mass index, risk factor profile, degree of coronary disease, left ventricular dysfunction, mode of presentation, initial pharmacological therapy and mortality data were compared between the three groups. RESULTS: 4549 patients were analysed of whom, 277 were less than 45 years old. Younger patients tended to be male, more overweight and present more commonly with ST segment elevation myocardial infarction compared to their older counterparts. Smoking, family history and dyslipidaemia tended to occur more frequently in younger patients as compared to those >45 years. Those patients >45 years tended to present with non-ST segment elevation myocardial infarction and have a higher degree of ischaemic burden and left ventricular dysfunction. No patients <45 years died in their index admission at 30 days or at one year. CONCLUSIONS: Although young patients <45 years make up the minority (6.1%) of patients presenting with acute coronary syndrome and generally have a favourable prognosis, this paper highlights the need for aggressive risk factor modification, with particular attention to smoking and dyslipidaemia, before the onset of overt clinical disease.
BACKGROUND: There is little data regarding the demographic profile of young (<45 years) Australian acute coronary syndromepatients. The aim of this study was to compare baseline characteristics, risk factor profile and outcomes of young patients compared with their older counterparts referred to two metropolitan Queensland hospitals. METHODS: Over a four-year period, data on acute coronary syndromepatients referred to The Prince Charles and Royal Brisbane Hospitals were retrospectively analysed. Three major groups were identified: <45 years, 45-60 years and those >60 years. Age, sex, body mass index, risk factor profile, degree of coronary disease, left ventricular dysfunction, mode of presentation, initial pharmacological therapy and mortality data were compared between the three groups. RESULTS: 4549 patients were analysed of whom, 277 were less than 45 years old. Younger patients tended to be male, more overweight and present more commonly with ST segment elevation myocardial infarction compared to their older counterparts. Smoking, family history and dyslipidaemia tended to occur more frequently in younger patients as compared to those >45 years. Those patients >45 years tended to present with non-ST segment elevation myocardial infarction and have a higher degree of ischaemic burden and left ventricular dysfunction. No patients <45 years died in their index admission at 30 days or at one year. CONCLUSIONS: Although young patients <45 years make up the minority (6.1%) of patients presenting with acute coronary syndrome and generally have a favourable prognosis, this paper highlights the need for aggressive risk factor modification, with particular attention to smoking and dyslipidaemia, before the onset of overt clinical disease.
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