Literature DB >> 23791620

Identification of a methicillin-resistant Staphylococcus aureus inhibitory compound isolated from Serratia marcescens.

Daniel E Kadouri1, Robert M Q Shanks.   

Abstract

In this study, we identified an antimicrobial compound produced by the Gram-negative bacterium Serratia marcescens. Colonies of S. marcescens inhibited the growth of nine different methicillin-resistant Staphylococcus aureus (MRSA) isolates and several other tested Gram-positive bacterial species, but not Gram-negative bacteria. Genetic analysis revealed the requirement for the swrW gene which codes for a non-ribosomal peptide synthetase that generates the cyclodepsipeptide antibiotic serratamolide, also known as serrawettin W1. This is the first report describing the anti-MRSA properties of serratamolide.
Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Aminolipid; Antibiotic; MRSA; Non-ribosomal peptide synthetase; Nosocomial infection; Secondary metabolite

Mesh：

Substances：

Year:  2013        PMID： 23791620      PMCID： PMC3770767          DOI： 10.1016/j.resmic.2013.06.002

Source DB:  PubMed          Journal:  Res Microbiol        ISSN： 0923-2508            Impact factor:   3.992


  20 in total

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Authors:  Su L Chiang; Eric J Rubin
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2.  Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.

Authors:  G BERTANI
Journal:  J Bacteriol       Date:  1951-09       Impact factor: 3.490

3.  A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR.

Authors:  V L Miller; J J Mekalanos
Journal:  J Bacteriol       Date:  1988-06       Impact factor: 3.490

4.  Increased cell surface hydrophobicity of a Serratia marcescens NS 38 mutant lacking wetting activity.

Authors:  R Bar-Ness; N Avrahamy; T Matsuyama; M Rosenberg
Journal:  J Bacteriol       Date:  1988-09       Impact factor: 3.490

5.  Serratia marcescens gene required for surfactant serrawettin W1 production encodes putative aminolipid synthetase belonging to nonribosomal peptide synthetase family.

Authors:  Hong Li; Taichiro Tanikawa; Yohei Sato; Yoji Nakagawa; Tohey Matsuyama
Journal:  Microbiol Immunol       Date:  2005       Impact factor: 1.955

6.  Biosynthesis of tripyrrole and beta-lactam secondary metabolites in Serratia: integration of quorum sensing with multiple new regulatory components in the control of prodigiosin and carbapenem antibiotic production.

Authors:  Peter C Fineran; Holly Slater; Lee Everson; Katie Hughes; George P C Salmond
Journal:  Mol Microbiol       Date:  2005-06       Impact factor: 3.501

Review 7.  Regulation and biosynthesis of carbapenem antibiotics in bacteria.

Authors:  Sarah J Coulthurst; Anne M L Barnard; George P C Salmond
Journal:  Nat Rev Microbiol       Date:  2005-04       Impact factor: 60.633

8.  Fractal spreading growth of Serratia marcescens which produces surface active exolipids.

Authors:  T Matsuyama; M Sogawa; Y Nakagawa
Journal:  FEMS Microbiol Lett       Date:  1989-10-15       Impact factor: 2.742

9.  SELECTIVE INHIBITION OF PROLINE-INDUCED PIGMENTATION IN WASHED CELLS OF SERRATIA MARCESCENS.

Authors:  J L BLIZZARD; G E PETERSON
Journal:  J Bacteriol       Date:  1963-05       Impact factor: 3.490

10.  A Serratia marcescens PigP homolog controls prodigiosin biosynthesis, swarming motility and hemolysis and is regulated by cAMP-CRP and HexS.

Authors:  Robert M Q Shanks; Roni M Lahr; Nicholas A Stella; Kristin E Arena; Kimberly M Brothers; Daniel H Kwak; Xinyu Liu; Eric J Kalivoda
Journal:  PLoS One       Date:  2013-03-01       Impact factor: 3.240
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  9 in total

1.  Identification of SlpB, a Cytotoxic Protease from Serratia marcescens.

Authors:  Robert M Q Shanks; Nicholas A Stella; Kristin M Hunt; Kimberly M Brothers; Liang Zhang; Patrick H Thibodeau
Journal:  Infect Immun       Date:  2015-05-04       Impact factor: 3.441

2.  An IgaA/UmoB Family Protein from Serratia marcescens Regulates Motility, Capsular Polysaccharide Biosynthesis, and Secondary Metabolite Production.

Authors:  Nicholas A Stella; Kimberly M Brothers; Jake D Callaghan; Angelina M Passerini; Cihad Sigindere; Preston J Hill; Xinyu Liu; Daniel J Wozniak; Robert M Q Shanks
Journal:  Appl Environ Microbiol       Date:  2018-03-01       Impact factor: 4.792

3.  Serratia marcescens Cyclic AMP Receptor Protein Controls Transcription of EepR, a Novel Regulator of Antimicrobial Secondary Metabolites.

Authors:  Nicholas A Stella; Roni M Lahr; Kimberly M Brothers; Eric J Kalivoda; Kristin M Hunt; Daniel H Kwak; Xinyu Liu; Robert M Q Shanks
Journal:  J Bacteriol       Date:  2015-04-20       Impact factor: 3.490

Review 4.  Pseudomonas putida-a versatile host for the production of natural products.

Authors:  Anita Loeschcke; Stephan Thies
Journal:  Appl Microbiol Biotechnol       Date:  2015-06-23       Impact factor: 4.813

5.  Role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10.

Authors:  Amy J Gerc; Nicola R Stanley-Wall; Sarah J Coulthurst
Journal:  Microbiology (Reading)       Date:  2014-05-20       Impact factor: 2.777

6.  Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants.

Authors:  Jennifer Hage-Hülsmann; Alexander Grünberger; Stephan Thies; Beatrix Santiago-Schübel; Andreas Sebastian Klein; Jörg Pietruszka; Dennis Binder; Fabienne Hilgers; Andreas Domröse; Thomas Drepper; Dietrich Kohlheyer; Karl-Erich Jaeger; Anita Loeschcke
Journal:  PLoS One       Date:  2018-07-19       Impact factor: 3.240

7.  Seed treatment with prodigiosin controls damping-off of cucumber caused by Pythium ultimum.

Authors:  Daniel P Roberts; Kaitlyn Selmer; Robert Lupitskyy; Clifford Rice; Jeffrey S Buyer; Jude E Maul; Dilip K Lakshman; Jorge DeSouza
Journal:  AMB Express       Date:  2021-01-06       Impact factor: 3.298

8.  Thermoregulation of Prodigiosin Biosynthesis by Serratia marcescens is Controlled at the Transcriptional Level and Requires HexS.

Authors:  Eric G Romanowski; Kara M Lehner; Natalie C Martin; Kriya R Patel; Jake D Callaghan; Nicholas A Stella; Robert M Q Shanks
Journal:  Pol J Microbiol       Date:  2019

9.  Biologically active pigment and ShlA cytolysin of Serratia marcescens induce autophagy in a human ocular surface cell line.

Authors:  Kimberly M Brothers; Nicholas A Stella; Robert M Q Shanks
Journal:  BMC Ophthalmol       Date:  2020-03-26       Impact factor: 2.209
  9 in total

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