Literature DB >> 237909

The in vitro biosynthesis of dhurrin, the cyanogenic glycoside of Sorghum bicolor.

I J MacFarlane, E M Lees, E E Conn.   

Abstract

A microsomal fraction from seedlings of Sorghum bicolor (Linn) Moench has been shown to catalyze the conversion of L-tyrosine to p-hydroxymandelonitrile via p-hydroxyphenylacetaldoxime. This transformation is consistent with the general pathway for cyanogenic glycoside biosynthesis proposed on the basis of in vivo experiments. When the microsomal fraction was combined with a protein fraction from the soluble portion of the cell and uridine diphosphate glucose, it was possible to demonstrate the synthesis of the cyanogenic glycoside dhurrin from L-tyrosine.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 237909

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  16 in total

1.  Transgenic tobacco and Arabidopsis plants expressing the two multifunctional sorghum cytochrome P450 enzymes, CYP79A1 and CYP71E1, are cyanogenic and accumulate metabolites derived from intermediates in Dhurrin biosynthesis.

Authors:  S Bak; C E Olsen; B A Halkier; B L Møller
Journal:  Plant Physiol       Date:  2000-08       Impact factor: 8.340

2.  Phenylalanine ammonia lyase and cinnamic acid hydroxylases as assembled consecutive enzymes on microsomal membranes of cucumber cotyledons: Cooperation and subcellular distribution.

Authors:  U Czichi; H Kindl
Journal:  Planta       Date:  1977-01       Impact factor: 4.116

3.  Tissue Distributions of Dhurrin and of Enzymes Involved in Its Metabolism in Leaves of Sorghum bicolor.

Authors:  M Kojima; J E Poulton; S S Thayer; E E Conn
Journal:  Plant Physiol       Date:  1979-06       Impact factor: 8.340

4.  Localization of Cinnamic Acid 4-Monooxygenase and the Membrane-bound Enzyme System for Dhurrin Biosynthesis in Sorghum Seedlings.

Authors:  J A Saunders; E E Conn; C H Lin; M Shimada
Journal:  Plant Physiol       Date:  1977-10       Impact factor: 8.340

Review 5.  Microorganisms and cyanide.

Authors:  C J Knowles
Journal:  Bacteriol Rev       Date:  1976-09

6.  Biosynthesis of cyanogenic glycosides.

Authors:  E E Conn
Journal:  Naturwissenschaften       Date:  1979-01

7.  Isolation and reconstitution of cytochrome P450ox and in vitro reconstitution of the entire biosynthetic pathway of the cyanogenic glucoside dhurrin from sorghum.

Authors:  R A Kahn; S Bak; I Svendsen; B A Halkier; B L Møller
Journal:  Plant Physiol       Date:  1997-12       Impact factor: 8.340

8.  2-nitro-3-(p-hydroxyphenyl)propionate and aci-1-nitro-2-(p-hydroxyphenyl)ethane, two intermediates in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench.

Authors:  B A Halkier; J Lykkesfeldt; B L Møller
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205

9.  Cyanide formation in preparations from Chlorella and New Zealand spinach leaves: Effect of added amino acids.

Authors:  H S Gewitz; E K Pistorius; H Voss; B Vennesland
Journal:  Planta       Date:  1976-01       Impact factor: 4.116

10.  Isolation of the heme-thiolate enzyme cytochrome P-450TYR, which catalyzes the committed step in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench.

Authors:  O Sibbesen; B Koch; B A Halkier; B L Møller
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.