Literature DB >> 23790484

Ins and outs of kinase DFG motifs.

Daniel K Treiber1, Neil P Shah.   

Abstract

In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known "gatekeeper" residue, regulate "in" versus "out" conformations of the conserved "DFG" motif. These findings suggest yet another role for the gatekeeper residue.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23790484     DOI： 10.1016/j.chembiol.2013.06.001

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  41 in total

1.  Allosteric modulation of a human protein kinase with monobodies.

Authors:  Adelajda Zorba; Vy Nguyen; Akiko Koide; Marc Hoemberger; Yuejiao Zheng; Steffen Kutter; Chansik Kim; Shohei Koide; Dorothee Kern
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-25       Impact factor: 11.205

2.  Vemurafenib Inhibits Active PTK6 in PTEN-null Prostate Tumor Cells.

Authors:  Darren J Wozniak; Ben Hitchinson; Milica B Gilic; Wenjun Bie; Vadim Gaponenko; Angela L Tyner
Journal:  Mol Cancer Ther       Date:  2019-03-29       Impact factor: 6.261

3.  Chemotherapeutic drug selectivity between wild-type and mutant BRaf kinases in colon cancer.

Authors:  Jianchun Zhang; Tao Ji
Journal:  J Mol Model       Date:  2016-12-05       Impact factor: 1.810

4.  Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.

Authors:  Zhiyong Liu; Robert A Galemmo; Kyle B Fraser; Mark S Moehle; Saurabh Sen; Laura A Volpicelli-Daley; Lawrence J DeLucas; Larry J Ross; Jacob Valiyaveettil; Omar Moukha-Chafiq; Ashish K Pathak; Subramaniam Ananthan; Hollis Kezar; E Lucile White; Vandana Gupta; Joseph A Maddry; Mark J Suto; Andrew B West
Journal:  J Biol Chem       Date:  2014-09-16       Impact factor: 5.157

5.  Structural Characterization of the Aurora Kinase B "DFG-flip" Using Metadynamics.

Authors:  Naga Rajiv Lakkaniga; Meenakshisundaram Balasubramaniam; Shuxing Zhang; Brendan Frett; Hong-Yu Li
Journal:  AAPS J       Date:  2019-12-18       Impact factor: 4.009

6.  MZH29 is a novel potent inhibitor that overcomes drug resistance FLT3 mutations in acute myeloid leukemia.

Authors:  B Xu; Y Zhao; X Wang; P Gong; W Ge
Journal:  Leukemia       Date:  2016-10-24       Impact factor: 11.528

7.  Pathogen Trojan Horse Delivers Bioactive Host Protein to Alter Maize Anther Cell Behavior in Situ.

Authors:  Karina van der Linde; Ljudmilla Timofejeva; Rachel L Egger; Birger Ilau; Reza Hammond; Chong Teng; Blake C Meyers; Gunther Doehlemann; Virginia Walbot
Journal:  Plant Cell       Date:  2018-02-15       Impact factor: 11.277

8.  A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.

Authors:  Jamie A Moroco; Matthew P Baumgartner; Heather L Rust; Hwan Geun Choi; Wooyoung Hur; Nathanael S Gray; Carlos J Camacho; Thomas E Smithgall
Journal:  Chem Biol Drug Des       Date:  2014-11-28       Impact factor: 2.817

Review 9.  Mechanisms of Resistance to ABL Kinase Inhibition in Chronic Myeloid Leukemia and the Development of Next Generation ABL Kinase Inhibitors.

Authors:  Ami B Patel; Thomas O'Hare; Michael W Deininger
Journal:  Hematol Oncol Clin North Am       Date:  2017-08       Impact factor: 3.722

Review 10.  Inhibitors of cyclin-dependent kinases as cancer therapeutics.

Authors:  Steven R Whittaker; Aurélie Mallinger; Paul Workman; Paul A Clarke
Journal:  Pharmacol Ther       Date:  2017-02-05       Impact factor: 12.310
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