BACKGROUND AND PURPOSE: Subthreshold depression (SubD) is characterized by clinically relevant depressive symptoms not meeting criteria for major depression. The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demented Parkinson's disease (PD) outpatients. METHODS: Amongst 115 patients, SubD was identified in 30 patients, major depression in 33; 36 patients were classified as non-depressed. Enrolled patients were administered tests and questionnaires validated in PD for assessing objective and subjective cognitive dysfunctions. RESULTS: On objective cognitive measures SubD patients did not differ from non-depressed patients, whereas depressed patients achieved significantly lower scores than the other two groups. SubD and depressed patients reported more cognitive complaints than non-depressed patients. CONCLUSIONS: SubD is a non-motor aspect of PD that is not related to objective cognitive deficits but is associated with subjective cognitive complaints, thus impacting on patients' well-being.
BACKGROUND AND PURPOSE: Subthreshold depression (SubD) is characterized by clinically relevant depressive symptoms not meeting criteria for major depression. The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demented Parkinson's disease (PD) outpatients. METHODS: Amongst 115 patients, SubD was identified in 30 patients, major depression in 33; 36 patients were classified as non-depressed. Enrolled patients were administered tests and questionnaires validated in PD for assessing objective and subjective cognitive dysfunctions. RESULTS: On objective cognitive measures SubD patients did not differ from non-depressedpatients, whereas depressedpatients achieved significantly lower scores than the other two groups. SubD and depressedpatients reported more cognitive complaints than non-depressedpatients. CONCLUSIONS: SubD is a non-motor aspect of PD that is not related to objective cognitive deficits but is associated with subjective cognitive complaints, thus impacting on patients' well-being.
Authors: Rachael Purri; Laura Brennan; Jacqueline Rick; Sharon X Xie; Benjamin L Deck; Lana M Chahine; Nabila Dahodwala; Alice Chen-Plotkin; John E Duda; James F Morley; Rizwan S Akhtar; John Q Trojanowski; Andrew Siderowf; Daniel Weintraub Journal: Mov Disord Date: 2020-06-10 Impact factor: 10.338
Authors: Raquel P Barbosa; Marcelo D Mendonça; André P Caetano; Tania M Lampreia; Rita Miguel; Paulo M Bugalho Journal: J Neural Transm (Vienna) Date: 2019-07-05 Impact factor: 3.575
Authors: Aline Schönenberg; Hannah M Zipprich; Ulrike Teschner; Julian Grosskreutz; Otto W Witte; Tino Prell Journal: Health Qual Life Outcomes Date: 2021-03-25 Impact factor: 3.186