| Literature DB >> 23790021 |
Ana Lúcia Cardoso1, Lourdes Gimeno, Américo Lemos, Francisco Palacios, Teresa M V D Pinho e Melo.
Abstract
The synthesis of 2-(tetrazol-5-yl)-2H-azirines is reported for the first time. Using the Neber approach, β-ketoxime-1H-tetrazoles were converted into the target 2H-azirines bearing phenyl, furan-2-yl, thiophen-2-yl, or pyrrol-2-yl substituents at C-3. It was demonstrated that the alkaloid-mediated Neber reaction allows the asymmetric synthesis of 2-(tetrazol-5-yl)-2H-azirines.Entities:
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Year: 2013 PMID： 23790021 DOI： 10.1021/jo4006552
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354