Enantiopure alkaloid mimics are synthesized via high yielding intramolecular cycloadditions of photogenerated azaxylylenes tethered to pyrroles, with further growth of molecular complexity via post-photochemical transformations of primary photoproducts. This expeditious access to structurally unprecedented polyheterocyclic cores is being developed in the context of diversity-oriented synthesis, as the modular design allows for rapid "pre-assembly" of diverse photoprecursors from simple building blocks/diversity inputs.
Enantiopure alkaloid mimics are n class="Gene">synthesized via high yielding intramolecular cycloadditions of photogenerated azaxylylenes tethered to pyrroles, with further growth of molecular complexity via post-photochemical transformations of primary photoproducts. This expeditious access to structurally unprecedented polyheterocyclic cores is being developed in the context of diversity-oriented synthesis, as the modular design allows for rapid "pre-assembly" of diverse photoprecursors from simple building blocks/diversity inputs.
Authors: Olga A Mukhina; N N Bhuvan Kumar; Teresa M Arisco; Roman A Valiulin; Greg A Metzel; Andrei G Kutateladze Journal: Angew Chem Int Ed Engl Date: 2011-08-31 Impact factor: 15.336
Authors: Saishuai Wen; Jonathan H Boyce; Sunil K Kandappa; Jayaraman Sivaguru; John A Porco Journal: J Am Chem Soc Date: 2019-07-02 Impact factor: 15.419
Authors: Olga A Mukhina; Dmitry M Kuznetsov; Teresa M Cowger; Andrei G Kutateladze Journal: Angew Chem Int Ed Engl Date: 2015-06-30 Impact factor: 15.336