Literature DB >> 23788489

A cascade coupling strategy for one-pot total synthesis of β-carboline and isoquinoline-containing natural products and derivatives.

Yan-Ping Zhu1, Mei-Cai Liu, Qun Cai, Feng-Cheng Jia, An-Xin Wu.   

Abstract

Multi-birds with one stone: A cascade coupling strategy was developed for the synthesis of β-carbolines. The method can direct the synthesis of β-carboline and isoquinoline-containing natural products with high yields. Moreover, this protocol can also be further applied towards the total synthesis of natural products fascaplysin and papaverin (see scheme).
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  CH coupling; carboline; cascade reactions; isoquinoline; natural products

Mesh：

Substances：

Year:  2013        PMID： 23788489     DOI： 10.1002/chem.201301734

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  6 in total

1.  Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues.

Authors:  Maxim E Zhidkov; Polina A Smirnova; Oleg A Tryapkin; Alexey V Kantemirov; Yuliya V Khudyakova; Olesya S Malyarenko; Svetlana P Ermakova; Valeria P Grigorchuk; Moritz Kaune; Gunhild von Amsberg; Sergey A Dyshlovoy
Journal:  Mar Drugs       Date:  2019-08-25       Impact factor: 5.118

Review 2.  Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria.

Authors:  Andre G Tempone; Pauline Pieper; Samanta E T Borborema; Fernanda Thevenard; Joao Henrique G Lago; Simon L Croft; Edward A Anderson
Journal:  Nat Prod Rep       Date:  2021-12-15       Impact factor: 13.423

3.  Morita-Baylis-Hillman reaction of 3-formyl-9H-pyrido[3,4-b]indoles and fluorescence studies of the products.

Authors:  Nisha Devi; Virender Singh
Journal:  Beilstein J Org Chem       Date:  2022-07-26       Impact factor: 2.544

4.  Synthesis of Diversified Pyrazolo[3,4-b]pyridine Frameworks from 5-Aminopyrazoles and Alkynyl Aldehydes via Switchable C≡C Bond Activation Approaches.

Authors:  Xiao-Yu Miao; Yong-Ji Hu; Fu-Rao Liu; Yuan-Yuan Sun; Die Sun; An-Xin Wu; Yan-Ping Zhu
Journal:  Molecules       Date:  2022-09-27       Impact factor: 4.927

5.  Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death.

Authors:  Pavel Spirin; Elena Shyrokova; Timofey Lebedev; Elmira Vagapova; Polina Smirnova; Alexey Kantemirov; Sergey A Dyshlovoy; Gunhild von Amsberg; Maxim Zhidkov; Vladimir Prassolov
Journal:  Mar Drugs       Date:  2021-08-27       Impact factor: 5.118

6.  Study of Structure-Activity Relationships of the Marine Alkaloid Fascaplysin and Its Derivatives as Potent Anticancer Agents.

Authors:  Maxim E Zhidkov; Moritz Kaune; Alexey V Kantemirov; Polina A Smirnova; Pavel V Spirin; Maria A Sidorova; Sergey A Stadnik; Elena Y Shyrokova; Dmitry N Kaluzhny; Oleg A Tryapkin; Tobias Busenbender; Jessica Hauschild; Tina Rohlfing; Vladimir S Prassolov; Carsten Bokemeyer; Markus Graefen; Gunhild von Amsberg; Sergey A Dyshlovoy
Journal:  Mar Drugs       Date:  2022-03-02       Impact factor: 5.118
  6 in total

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