Literature DB >> 23787620

A complete and computationally efficient numerical model of aplanatic solid immersion lens scanning microscope.

Rui Chen1, Krishna Agarwal, Colin J R Sheppard, Jacob C H Phang, Xudong Chen.   

Abstract

This paper presents a computational model for modeling an aplanatic solid immersion lens scanning microscope. The scanning microscope model consists of three subsystems, each of which can be computed as a separate system, connected to the preceding or succeeding subsystem through the input/output only. Numerical techniques are used to enhance the computational efficiency of each subsystem. A distinct merit of the proposed model is that it can be used to simulate imaging results for diverse setups of the scanning microscope, like various polarizations, numerical aperture, and different detector pinhole sizes. It allows the study and analysis of both theoretical aspects like achievable resolution, and practical aspects like expected images for different object patterns and experimental setups. Further, due to its computational efficiency, diverse large scale structures can be easily simulated in scanning microscope and good experimental approaches determined before indulging into the time consuming and costly process of experimentation.

Mesh:

Year:  2013        PMID: 23787620     DOI: 10.1364/OE.21.014316

Source DB:  PubMed          Journal:  Opt Express        ISSN: 1094-4087            Impact factor:   3.894


  2 in total

1.  Super-resolution Microscopy at Cryogenic Temperatures Using Solid Immersion Lenses.

Authors:  Benji C Bateman; Laura C Zanetti-Domingues; Amy N Moores; Sarah R Needham; Daniel J Rolfe; Lin Wang; David T Clarke; Marisa L Martin-Fernandez
Journal:  Bio Protoc       Date:  2019-11-20

2.  Solid immersion microscopy images cells under cryogenic conditions with 12 nm resolution.

Authors:  Lin Wang; Benji Bateman; Laura C Zanetti-Domingues; Amy N Moores; Sam Astbury; Christopher Spindloe; Michele C Darrow; Maria Romano; Sarah R Needham; Konstantinos Beis; Daniel J Rolfe; David T Clarke; Marisa L Martin-Fernandez
Journal:  Commun Biol       Date:  2019-02-21
  2 in total

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