Literature DB >> 23787558

Modern Vaccines/Adjuvants Formulation Session 6: Vaccine &Adjuvant Formulation & Production 15-17 May 2013, Lausanne, Switzerland.

Christopher B Fox1.   

Abstract

The Modern Vaccines/Adjuvants Formulation meeting aims to fill a critical gap in current vaccine development efforts by bringing together formulation scientists and immunologists to emphasize the importance of rational formulation design in order to optimize vaccine and adjuvant bioactivity, safety, and manufacturability. Session 6 on Vaccine and Adjuvant Formulation and Production provided three examples of this theme, with speakers emphasizing the need for extensive physicochemical characterization of adjuvant-antigen interactions, the rational formulation design of a CD8+ T cell-inducing adjuvant based on immunological principles, and the development and production of a rabies vaccine by a developing country manufacturer. Throughout the session, the practical importance of sound formulation and manufacturing design accompanied by analytical characterization was highlighted.

Entities:  

Keywords:  formulation; manufacturing; nanoparticles; physicochemical characterization; vaccine adjuvant

Mesh:

Substances:

Year:  2013        PMID: 23787558      PMCID: PMC3906369          DOI: 10.4161/hv.25340

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN: 2164-5515            Impact factor:   3.452


  6 in total

1.  Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response.

Authors:  Malou Henriksen-Lacey; Dennis Christensen; Vincent W Bramwell; Thomas Lindenstrøm; Else Marie Agger; Peter Andersen; Yvonne Perrie
Journal:  J Control Release       Date:  2010-04-08       Impact factor: 9.776

2.  Working together: interactions between vaccine antigens and adjuvants.

Authors:  Christopher B Fox; Ryan M Kramer; Lucien Barnes V; Quinton M Dowling; Thomas S Vedvick
Journal:  Ther Adv Vaccines       Date:  2013-05

3.  A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog.

Authors:  Dennis Christensen; Malou Henriksen-Lacey; Arun T Kamath; Thomas Lindenstrøm; Karen S Korsholm; Jan P Christensen; Anne-Francoise Rochat; Paul-Henri Lambert; Peter Andersen; Claire-Anne Siegrist; Yvonne Perrie; Else Marie Agger
Journal:  J Control Release       Date:  2012-03-27       Impact factor: 9.776

4.  Characterization of rabies virus from a human case in Nepal.

Authors:  G R Pant; D L Horton; M Dahal; J N Rai; S Ide; S Leech; D A Marston; L M McElhinney; A R Fooks
Journal:  Arch Virol       Date:  2011-02-06       Impact factor: 2.574

5.  TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection.

Authors:  Ivett Jelinek; Joshua N Leonard; Graeme E Price; Kevin N Brown; Anna Meyer-Manlapat; Paul K Goldsmith; Yan Wang; David Venzon; Suzanne L Epstein; David M Segal
Journal:  J Immunol       Date:  2011-01-17       Impact factor: 5.422

6.  Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

Authors:  Claire A Swetman Andersen; Ida Rosenkrands; Anja W Olsen; Pernille Nordly; Dennis Christensen; Roland Lang; Carsten Kirschning; Jessica M Gomes; Veemal Bhowruth; David E Minnikin; Gurdyal S Besra; Frank Follmann; Peter Andersen; Else Marie Agger
Journal:  J Immunol       Date:  2009-07-20       Impact factor: 5.422

  6 in total
  2 in total

Review 1.  Epidemiology, Impact and Control of Rabies in Nepal: A Systematic Review.

Authors:  Brecht Devleesschauwer; Arjun Aryal; Barun Kumar Sharma; Anita Ale; Anne Declercq; Stephanie Depraz; Tara Nath Gaire; Gyanendra Gongal; Surendra Karki; Basu Dev Pandey; Sher Bahadur Pun; Luc Duchateau; Pierre Dorny; Niko Speybroeck
Journal:  PLoS Negl Trop Dis       Date:  2016-02-12

2.  The influence of adjuvant on UreB protection against Helicobacter pylori through the diversity of CD4+ T-cell epitope repertoire.

Authors:  Bin Li; Hanmei Yuan; Li Chen; Heqiang Sun; Jian Hu; Shanshan Wei; Zhuo Zhao; Quanming Zou; Chao Wu
Journal:  Oncotarget       Date:  2017-07-12
  2 in total

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