Literature DB >> 23787049

Tumor suppression: p53 alters immune surveillance to restrain liver cancer.

Nitin Raj1, Laura D Attardi.   

Abstract

The p53 tumor suppressor governs multiple cell-intrinsic programs, including cell-cycle arrest and apoptosis, to curb neoplastic growth. A new study reveals that p53 also acts through a novel non-cell-autonomous mechanism, by stimulating the innate immune system to maintain tissue homeostasis and suppress tumorigenesis.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23787049      PMCID： PMC4077325          DOI： 10.1016/j.cub.2013.04.076

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  13 in total

1.  Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.

Authors:  Wen Xue; Lars Zender; Cornelius Miething; Ross A Dickins; Eva Hernando; Valery Krizhanovsky; Carlos Cordon-Cardo; Scott W Lowe
Journal:  Nature       Date:  2007-01-24       Impact factor: 49.962

Review 2.  Blinded by the Light: The Growing Complexity of p53.

Authors:  Karen H Vousden; Carol Prives
Journal:  Cell       Date:  2009-05-01       Impact factor: 41.582

3.  Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.

Authors:  Reginald Hill; Yurong Song; Robert D Cardiff; Terry Van Dyke
Journal:  Cell       Date:  2005-12-16       Impact factor: 41.582

Review 4.  Senescence in tumours: evidence from mice and humans.

Authors:  Manuel Collado; Manuel Serrano
Journal:  Nat Rev Cancer       Date:  2010-01       Impact factor: 60.716

5.  A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.

Authors:  Clemens A Schmitt; Jordan S Fridman; Meng Yang; Soyoung Lee; Eugene Baranov; Robert M Hoffman; Scott W Lowe
Journal:  Cell       Date:  2002-05-03       Impact factor: 41.582

Review 6.  Macrophages: master regulators of inflammation and fibrosis.

Authors:  Thomas A Wynn; Luke Barron
Journal:  Semin Liver Dis       Date:  2010-07-21       Impact factor: 6.115

Review 7.  The senescence-associated secretory phenotype: the dark side of tumor suppression.

Authors:  Jean-Philippe Coppé; Pierre-Yves Desprez; Ana Krtolica; Judith Campisi
Journal:  Annu Rev Pathol       Date:  2010       Impact factor: 23.472

8.  Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

Authors:  Jean-Philippe Coppé; Christopher K Patil; Francis Rodier; Yu Sun; Denise P Muñoz; Joshua Goldstein; Peter S Nelson; Pierre-Yves Desprez; Judith Campisi
Journal:  PLoS Biol       Date:  2008-12-02       Impact factor: 8.029

9.  Senescence of activated stellate cells limits liver fibrosis.

Authors:  Valery Krizhanovsky; Monica Yon; Ross A Dickins; Stephen Hearn; Janelle Simon; Cornelius Miething; Herman Yee; Lars Zender; Scott W Lowe
Journal:  Cell       Date:  2008-08-22       Impact factor: 41.582

10.  Non-cell-autonomous tumor suppression by p53.

Authors:  Amaia Lujambio; Leila Akkari; Janelle Simon; Danielle Grace; Darjus F Tschaharganeh; Jessica E Bolden; Zhen Zhao; Vishal Thapar; Johanna A Joyce; Valery Krizhanovsky; Scott W Lowe
Journal:  Cell       Date:  2013-04-04       Impact factor: 41.582
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  13 in total

Review 1.  An essential role for the immune system in the mechanism of tumor regression following targeted oncogene inactivation.

Authors:  Stephanie C Casey; Yulin Li; Dean W Felsher
Journal:  Immunol Res       Date:  2014-05       Impact factor: 2.829

2.  TP53 missense mutation is associated with increased tumor-infiltrating T cells in primary prostate cancer.

Authors:  Harsimar B Kaur; Jiayun Lu; Liana B Guedes; Laneisha Maldonado; Logan Reitz; John R Barber; Angelo M De Marzo; Scott A Tomlins; Karen S Sfanos; Mario Eisenberger; Edward M Schaeffer; Corinne E Joshu; Tamara L Lotan
Journal:  Hum Pathol       Date:  2019-03-06       Impact factor: 3.466

Review 3.  Emerging roles of p53 and other tumour-suppressor genes in immune regulation.

Authors:  César Muñoz-Fontela; Anna Mandinova; Stuart A Aaronson; Sam W Lee
Journal:  Nat Rev Immunol       Date:  2016-09-26       Impact factor: 53.106

Review 4.  Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome.

Authors:  Gerwyn Morris; Michael Berk; Hans Klein; Ken Walder; Piotr Galecki; Michael Maes
Journal:  Mol Neurobiol       Date:  2016-06-23       Impact factor: 5.590

5.  p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine.

Authors:  Fang Zheng; Qin Tang; JingJing Wu; ShunYu Zhao; ZhanYang Liang; Liuning Li; WanYin Wu; Swei Hann
Journal:  J Exp Clin Cancer Res       Date:  2014-04-26

Review 6.  The emerging role of alternative splicing in senescence and aging.

Authors:  Mathieu Deschênes; Benoit Chabot
Journal:  Aging Cell       Date:  2017-07-13       Impact factor: 9.304

7.  Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation.

Authors:  M Charni; A Molchadsky; I Goldstein; H Solomon; P Tal; N Goldfinger; P Yang; Z Porat; G Lozano; V Rotter
Journal:  Cell Death Differ       Date:  2015-09-11       Impact factor: 15.828

8.  Effects of recombinant human adenovirus-p53 on the regression of hepatic fibrosis.

Authors:  Yehong Liu; Puye Yang; Na Chen; Shumei Lin; Min Liu
Journal:  Int J Mol Med       Date:  2016-08-26       Impact factor: 4.101

9.  Reconstructing the molecular life history of gliomas.

Authors:  Floris P Barthel; Pieter Wesseling; Roel G W Verhaak
Journal:  Acta Neuropathol       Date:  2018-04-03       Impact factor: 17.088

10.  P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma.

Authors:  Caterina Costa; Paola Indovina; Eliseo Mattioli; Iris Maria Forte; Carmelina Antonella Iannuzzi; Luca Luzzi; Cristiana Bellan; Simona De Summa; Enrico Bucci; Domenico Di Marzo; Marisa De Feo; Luciano Mutti; Francesca Pentimalli; Antonio Giordano
Journal:  Cell Death Dis       Date:  2020-09-14       Impact factor: 8.469
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