A Sonnenberg1. 1. Portland VA Medical Center, Oregon Health & Science University, Portland, OR 97239, USA. sonnenbe@ohsu.edu
Abstract
BACKGROUND: The long-term time trends of multiple gastrointestinal diseases are characterised by a striking rise and fall. These temporal changes provide important clues about disease aetiology. AIM: To highlight the importance of Helicobacter pylori infection in shaping the temporal trends of many common gastrointestinal diseases. METHODS: Literature review of the time trends associated with common digestive diseases. RESULTS: The general trends of gastric ulcer, duodenal ulcer, gastric cancer, colon cancer, rectum cancer have all been shaped by a similar underlying birth-cohort phenomenon. Mortality associated with these diagnoses increased in all generations born during the nineteenth century. It peaked among generations born shortly before the turn of the century and then decreased in all subsequent generations born throughout the twentieth century. These patterns can be observed in the incidence, hospitalisation and mortality data from many different countries. They reflect similar rising and falling trends of H. pylori infection in the general population. Diseases that are inversely associated with H. pylori, such as reflux disease, erosive oesophagitis, Barrett's oesophagus, and oesophageal adenocarcinoma, have seen a striking rise during the recent decline of H. pylori infection. CONCLUSION: The temporal variations of H. pylori infection have affected the occurrence of gastroenterology's most common disorders. Published 2013. This article is a US Government work and is in the public domain in the USA.
BACKGROUND: The long-term time trends of multiple gastrointestinal diseases are characterised by a striking rise and fall. These temporal changes provide important clues about disease aetiology. AIM: To highlight the importance of Helicobacter pyloriinfection in shaping the temporal trends of many common gastrointestinal diseases. METHODS: Literature review of the time trends associated with common digestive diseases. RESULTS: The general trends of gastric ulcer, duodenal ulcer, gastric cancer, colon cancer, rectum cancer have all been shaped by a similar underlying birth-cohort phenomenon. Mortality associated with these diagnoses increased in all generations born during the nineteenth century. It peaked among generations born shortly before the turn of the century and then decreased in all subsequent generations born throughout the twentieth century. These patterns can be observed in the incidence, hospitalisation and mortality data from many different countries. They reflect similar rising and falling trends of H. pyloriinfection in the general population. Diseases that are inversely associated with H. pylori, such as reflux disease, erosive oesophagitis, Barrett's oesophagus, and oesophageal adenocarcinoma, have seen a striking rise during the recent decline of H. pyloriinfection. CONCLUSION: The temporal variations of H. pyloriinfection have affected the occurrence of gastroenterology's most common disorders. Published 2013. This article is a US Government work and is in the public domain in the USA.
Authors: Lars Agréus; Per M Hellström; Nicholas J Talley; Bengt Wallner; Anna Forsberg; Michael Vieth; Lothar Veits; Karin Björkegren; Lars Engstrand; Anna Andreasson Journal: United European Gastroenterol J Date: 2015-12-18 Impact factor: 4.623
Authors: Mohammad H Derakhshan; Melina Arnold; David H Brewster; James J Going; David R Mitchell; David Forman; Kenneth E L McColl Journal: Am J Gastroenterol Date: 2016-01-12 Impact factor: 10.864
Authors: R H Hunt; M Camilleri; S E Crowe; E M El-Omar; J G Fox; E J Kuipers; P Malfertheiner; K E L McColl; D M Pritchard; M Rugge; A Sonnenberg; K Sugano; J Tack Journal: Gut Date: 2015-09-04 Impact factor: 23.059