Literature DB >> 23786211

Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity.

A Brianne Thrush1, Robert Dent, Ruth McPherson, Mary-Ellen Harper.   

Abstract

Understanding the metabolic factors that contribute to obesity development and weight loss success are critical for combating obesity and obesity-related disorders. This review provides an overview of energy metabolism with a particular focus on mitochondrial function in health and in obesity. Mitochondrial proton leak contributes significantly to whole body energy expenditure and the potential role of energy uncoupling in weight loss success is discussed. We provide evidence to support the hypothesis that differences in energy efficiency are important regulators of body weight and weight loss success.
© 2013 FEBS.

Entities:  

Keywords:  diet resistance; mitochondria; obesity; oxidative phosphorylation; proton leak; uncoupling; weight loss

Mesh：

Substances：

Year:  2013        PMID： 23786211     DOI： 10.1111/febs.12399

Source DB:  PubMed          Journal:  FEBS J        ISSN： 1742-464X            Impact factor:   5.542


  13 in total

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Journal:  Obesity (Silver Spring)       Date:  2015-04-10       Impact factor: 5.002

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8.  Damaged mitochondria in Fanconi anemia - an isolated event or a general phenomenon?

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10.  Metabolic adaptation to weight loss: implications for the athlete.

Authors:  Eric T Trexler; Abbie E Smith-Ryan; Layne E Norton
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